5-羟色胺1A受体基因C（-1019）G（rs6295）单核苷酸多态性与中国汉族人群焦虑障碍的关联分析

Association between polymorphisms of 5-HT1A receptor gene C(-1019)G (rs6295) and anxiety disorder in Chinese Han population

摘要:

目的  探究5-羟色胺1A受体（5-HT1AR）基因C（-1019）G（rs6295）单核苷酸多态性（SNP）是否与中国汉族人群焦虑障碍[广泛焦虑障碍（GAD）和惊恐障碍（PD）]相关。方法  采用连接酶反应技术（LDR）检测5-HT1AR基因C（-1019）G（rs6295）SNP在319例焦虑障碍患者（210例GAD患者和109例PD患者）及300例健康者（对照组）中的分布，根据精神障碍诊断与统计手册（DSM-IV）诊断系统诊断GAD和PD。另外，比较5-HT1AR基因C（-1019）G（rs6295）SNP在GAD+PD组、对照组之间的性别差异。结果  GAD+PD组与对照组5-HT1AR基因C（-1019）G（rs6295）SNP的基因型和等位基因频度比较，差异无统计学意义（P >0.05）。结论  由于缺少相关联的证据，5-HT1AR基因C（-1019）G（rs6295）可能不是汉族人群焦虑障碍有标志性意义的位点。

关键词:

5-羟色胺1A受体;基因C（-1019）G;焦虑障碍;广泛焦虑障碍;惊恐障碍

Abstract:

Objective To explore the possible association between single nucleotide polymorphisms (SNPs) of 5-hydroxytryptamine 1A receptor (5-HT1AR) gene C(-1019)G (rs6295) and anxiety disorder [general anxiety disorder (GAD) and panic disorder (PD)] in Chinese Han population. Methods SNP of 5-HT1AR gene C(-1019)G (rs6295) were analyzed by a ligase detection reaction (LDR)-based method in 319 anxiety disorder cases (210 GAD cases and 109 PD cases) and 300 unrelated, sex-matched healthy control subjects. GAD and PD were diagnosed by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. In addition, polymorphisms of 5-HT1AR gene were compared between male and female cases of anxiety and controls. Results No significant difference was observed between the anxiety patients and the healthy controls in the genotype distribution and allele frequencies of the 5-HT1AR gene C(-1019)G. Similarly, no significant diffe-rences were found between male and female cases in the GAD cases and PD cases. Conclusions 5-HT1AR C(-1019)G may not be iconic locus in the Chinese Han population with anxiety disorders because of lack of evidence.

Key words:

5-HT1AR; C(-1019)G; anxiety disorder; general anxiety disorder; panic disorder