大蒜素体外抗猴甲型轮状病毒的研究

Effect of garlicin on Simian rotavirus A in vitro

摘要:

目的  研究大蒜素体外抗猴甲型轮状病毒（SA11）的作用。方法  通过病毒滴度测定来确定大蒜素能否抗SA11以及最佳浓度。结果  大蒜素对MA104细胞的最大无毒浓度为100 mg/ml，病毒滴度测定可以得出，50 mg/ml的大蒜素可以抑制SA11感染的MA104细胞出现细胞病变效应（CPE）。结论  一定浓度的大蒜素在体外有抗SA11的作用。

Abstract:

Objective To investigate the effect of garlicin on Simian rotavirus A (SA11) in vitro. Methods Various concentrations of garlicin were used to inhibit SA11 replication so as to find out the best concentration for the inhibition. Results The maximal nontoxic concentration of garlicin for MA104 cells was 100 mg/ml. Tissue culture revealed that 50 mg/ml garlicin could inhibit the cytopathic effect of MA104 cells infected by SA11. Conclusions Garlicin could produce obvious inhibitory effects on Simian rotavirus A in vitro.