血清β2微球蛋白与2型糖尿病患者认知功能障碍的相关性研究

Association of serum β2-microglobulin with cognitive function in type 2 diabetes patients

摘要:

目的  研究血清β2微球蛋白与2型糖尿病（T2DM）患者认知功能障碍的相关性。方法  选取2015年6月-2015年10月在唐山市工人医院内分泌科住院的T2DM患者186例为病例组，同期体检健康者150例为正常组，收集其人口学资料及临床检验指标。采用放射免疫定量分析方法检测血清β2-MG水平，应用可重复的成套神经心理状态测量量表对所有人认知功能进行评定。结果  ①与正常组比较，T2DM组患者血清β2-MG水平明显升高（P <0.01）；②与正常组比较，T2DM组RBANS量表即时记忆、视觉广度、言语功能、注意力、延迟记忆、总分降低（P <0.05）；③在T2DM患者中，与低β2-MG水平组比较，高β2-MG水平组即时记忆、视觉广度、言语功能、注意力、延迟记忆评分以及总分更低（P <0.05）；④在T2DM患者中，β2-MG水平与即刻记忆、视觉广度、言语功能、注意力、总分成负相关（P <0.05）。结论  血清β2-MG水平上升是T2DM患者出现认知功能降低的危险因素之一。

Abstract:

Objective To investigate the association of β2-microglobulin (β2-MG) with cognitive dysfunction in T2DM patients. Methods In this study 186 T2DM patients cared at Tangshan Gongren Hospital and 150 controls without T2DM from the Medical Examination Center from June 2015 to October 2015 were recruited. Data on demographic characteristics and clinical parameters were collected. β2-MG was measured by immunocapture act. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results Serum β2-MG of the T2DM patients was higher than that of the controls (P < 0.01). RBANS scores in the T2DM patients were lower than those of the controls on the total score and all subtest scores (P < 0.05). In the T2DM patients, the immediate memory, visuospatial/constructional, language, attention and delayed memory scores and the total score of the patients with higher β2-MG were lower than those of the patients with lower β2-MG (P < 0.05). In the T2DM patients, β2-MG level was negatively correlated with immediate memory, visuospatial/constructional, language, attention and total scores (P < 0.01). Conclusions Increased β2-MG level may be one of the risk factors for cognitive dysfunctiones of T2DM patients.