T2?鄢值评价健康成年人脑铁含量及其与性别的相关性研究

Study of gender-related iron deposition in brain using T2* value

摘要:

目的  采用3.0T磁敏感加权成像定量测量健康成年人额叶白质区及灰质核团的T2?鄢值，探讨灰质核团与性别的相关性。方法  选取年龄25～85岁的128例年龄相匹配的男性组及女性组进行磁共振成像（MRI）常规及磁敏感加权成像（SWI）扫描，经后处理在T2?鄢图像上分别测量左右侧额叶白质区、红核、黑质网状带、黑质致密带、尾状核头、壳核、苍白球和丘脑的T2?鄢值，分析T2?鄢值与性别的相关性。结果  男、女性组左、右侧的T2?鄢值在苍白球最低，其次为黑质网状带、红核，额叶白质区的最高。男性组右侧黑质网状带、黑质致密带T2?鄢值小于左侧，女性组右侧黑质网状带T2?鄢值小于左侧（P <0.05）。壳核、丘脑的T2?鄢值男、女性组比较，差异有统计学意义（P <0.05）；其余感兴趣区的T2?鄢值比较差异无统计学意义（P >0.05）。结论  健康成年人的壳核、丘脑的脑铁含量与性别具有相关性。

Abstract:

Objective To quantitatively analyze the iron deposition in deep brain gray nuclei and frontal white matter in healthy population and its correlation with gender using susceptibility-weighted imaging (SWI) with 3.0 Tesla scanner. Methods A total of 128 healthy subjects (64 males and 64 females, aged 25 to 85 years) were scanned with routine sequences and SWI sequences by 3.0T MR. T2* value was measured in left and right frontal white matter, red nucleus, substantia nigra pars reticulata, substantia nigra pars compacta, globus pallidus, putamen, head of caudate nucleus and thalamus; the correlations between the T2* value and gender were analyzed. Results The T2* value was the lowest in the globus pallidus, followed by substantia nigra reticulata and red nuclei. The highest T2* value was seen in the frontal white matter. The T2* value of the right substantia nigra compacta and substantia nigra pars reticulata was lower than that of the left-side one in the males (P < 0.05), and the T2* value of the right substantia nigra pars reticulate was lower than that of the left-side one in the females (P < 0.05). The T2* value of putamen and thalamus was significantly different between the males and the females (P < 0.05). Conclusions Using T2* value, a significant correlation has been found between putamen and thalamus iron deposition and gender in health population.