2型糖尿病合并甲状腺功能减退相关危险因素的Logistic回归分析

Logistic regression analysis of risk factors associated with type 2 diabetes mellitus combined with hypothyroidism

摘要:

目的  探讨2型糖尿病合并甲状腺功能减退的相关危险因素。方法  选取2013年1月-2015年1月于贵州省铜仁市人民医院内分泌科病房住院的2型糖尿病合并甲状腺功能减退患者64例作为病例组研究对象，随机抽取同期本院住院的2型糖尿病患者128例作为对照组研究对象，收集两组研究对象的临床资料，并进行相关危险因素的Logistic回归分析。结果  单因素非条件Logistic回归分析发现：胰岛素治疗及二甲双胍治疗是2型糖尿病合并甲状腺功能减退的保护因素（■=0.195、0.541，95%CI：0.084，0.232；0.216，0.838）；糖尿病肾病、脂代谢紊乱、高纤维蛋白原血症、吸烟史、HbAlc高以及TPO-Ab阳性是2型糖尿病合并甲状腺功能减退的危险因素（■=8.440、4.276、6.678、6.266、1.813、6.131，95%CI：3.140，13.467；1.106，5.978；2.340，9.015；2.135，8.249；1.017，2.826；2.338，9.059）；多因素非条件Logistic回归分析发现胰岛素治疗是2型糖尿病合并甲状腺功能减退的保护因素（■=0.198，95%CI：0.081，0.246）；糖尿病肾病、吸烟史、TPO-Ab阳性均是2型糖尿病合并甲状腺功能减退的危险因素（■=8.398、6.240、6.080，95%CI：3.132，13.514；2.101，8.568；2.324，8.942）。结论  胰岛素治疗、糖尿病肾病、吸烟史、TPO-Ab阳性均与2型糖尿病合并甲状腺功能减退有相关性，对于患有糖尿病肾病、有吸烟史和TPO-Ab阳性的2型糖尿病患者，应定期监测甲状腺功能。

关键词:

2型糖尿病;甲状腺功能减退;危险因素;Logistic回归分析

Abstract:

Objective To investigate the related risk factors of type 2 diabetes mellitus combined with hypothyroidism. Methods From Jan 2013 to Jan 2015, 64 patients with type 2 diabetes mellitus combined with hypothyroidism in our hospital were selected as the case group, 128 patients with type 2 diabetes mellitus were randomly selected as the control group. The clinical data of the two groups were collected and analyzed by Logistic regression analysis. Results Single factor non conditional Logistic regression analysis showed that insulin therapy and metformin treatment were protective factors of type 2 diabetes mellitus with hypothyroidism( ■ = 0.195, 0.541. 95% CI = 0.084-0.232, 0.216-0.838 ). Diabetic nephropathy, lipid metabolism disorders, high fibrinogen, smoking history, high HbAlc and TPO-Ab positive were risk factors for type 2 diabetes mellitus combined with hypothyroidism (■ = 8.440, 4.276, 6.678, 6.266, 1.813, 6.131. 95% CI = 3.140-13.467, 1.106-5.978, 2.340-9.015, 2.135-8.249, 1.017-2.826, 2.338-9.059). Multiple factor non conditional Logistic regression analysis found that insulin therapy was a protective factor for type 2 diabetes mellitus with hypothyroidism(■ = 0.198, 95% CI = 0.081-0.246 ). Diabetic nephropathy, smoking history, and TPO-Ab positive were risk factors for type 2 diabetes mellitus combined with hypothyroidism(■ = 8.398, 6.240, 6.080. 95% CI = 3.132-13.514, 2.101-8.568, 2.324-8.942 ). Conclusions Insulin therapy, diabetic nephropathy, smoking history, TPO-Ab positive are associated with type 2 diabetes mellitus combined with hypothyroidism. Type 2 diabetes with diabetes mellitus, smoking history, TPO-Ab positive should be regularly monitor their thyroid function.

Key words:

 ;type 2 diabetes mellitus; hypothyroidism; risk factor; Logistic regression analysis