糖尿病视网膜病变患者血清脂氧素A4和血管内皮生长因子的相关性研究

Association of serum lipoxins A4 and VEGF with diabetic retinopathy

摘要:

目的  研究血清脂氧素A4（LXA4）和血管内皮生长因子（VEGF）与糖尿病视网膜病变（DR）的相关性。方法  选取90例糖尿病患者按视网膜病变程度分为糖尿病无视网膜病变组（NDR）、单纯型糖尿病视网膜病变组（SDR）和增殖型糖尿病视网膜病变组（PDR），另选健康体检者40例作为正常对照组。测定各组血清LXA4和VEGF浓度，并研究LXA4和VEGF的相关性。结果  ①NDR、SDR和PDR组血清LXA4水平均低于NC组；SDR、PDR组血清LXA4水平低于NDR组；PDR组血清LXA4水平均低于SDR组，差异有统计学意义（P <0.05）。②NDR组血清VEGF水平与NC组比较，差异无统计学意义（P >0.05）；SDR、PDR组血清VEGF水平高于NDR组、NC组；PDR组血清VEGF水平高于SDR组，差异有统计学意义（P <0.05）。③血清LXA4和VEGF呈负相关（P <0.05）。结论  血清LXA4水平下降、VEGF水平上升可能是糖尿病患者出现视网膜病变的危险因素。

Abstract:

Objective To investigate the association of lipoxins A4 (LXA4) and vascular endothelial growth factor (VEGF) with diabetic retinopathy (DR). Methods Ninety diabetic patients were divided into three groups, i.e. no diabetic retinopathy (NDR) group, simple diabetic retinopathy (SDR) group and proliferative diabetic retinopathy (PDR) group. And 40 normal persons were recruited as the control group. The serum levels of LXA4 and VEGF were examined, and relationship between LXA4 and VEGF was also investigated. Results The serum LXA4 levels in the NDR, SDR and PDR groups were lower than that in the control group (P = 0.000). The serum LXA4 levels in the PDR and SDR groups were lower than that in the NDR group (P < 0.05). The serum LXA4 level in the PDR group was lower than that in the SDR group (P < 0.05). There was no statistical difference in VEGF between the NDR and control groups (P > 0.05). The serum VEGF level was higher in the SDR and PDR groups than in the NDR and control groups (P = 0.001), and it was also higher in the PDR group than in the SDR group (P < 0.05). Serum LXA4 level was negatively correlated with VEGF level (P < 0.05). Conclusions Decreased LXA4 and increased VEGF levels in serum may be the risk factors  of retinopathy in diabetic patients.