膀胱黏膜毒蕈碱型胆碱能受体密度与前列腺术后膀胱痉挛的相关性研究

Correlation study between density of muscarinic receptors in bladder mucosa and bladder spasm after prostate surgery

摘要:

目的  探讨膀胱黏膜毒蕈碱型胆碱能受体（M受体）M2、M3亚型的密度与前列腺电切术后膀胱痉挛的相关性。方法  选取2012年5月-2015年5月医院收治的良性前列腺增生（BPH）患者作为研究对象，将其分为合并膀胱过度活动症（OAB）观察组和不合并OAB对照组，再将观察组分为发生膀胱痉挛组及不发生膀胱痉挛组，比较各组M2、M3受体的密度及其相关性。结果  观察组术后膀胱痉挛的发生率高于对照组；观察组M2、M3受体密度均低于对照组；观察组中发生膀胱痉挛患者的M3受体密度低于不发生膀胱痉挛患者的M3受体密度。结论  膀胱黏膜M3受体密度与前列腺术后发生膀胱痉挛存在相关性，提示M3受体可能参与膀胱痉挛的发病机制。

Abstract:

Objective To analyze the correlation of the bladder spasm after prostate surgery and the density of M2 and M3 muscarinic receptors in bladder mucosa. Methods Patients with benign prostatic hyperplasia (BPH) in our hospital from May 2012 to May 2015 were enrolled as research objects and divided into observation group [BPH with overactive bladder (OAB)] and control group (BPH without OAB). And then the observation group was further divided into bladder spasm subgroup and non-spasm subgroup. The density of M2 and M3 receptors were determined and their correlations with bladder spasm were analyzed. Results The rate of bladder spasm of the observation group was higher than that of the control group. The density of M2 and M3 muscarinic receptors of the observation group was lower than that of the control group. The density of M3 muscarinic receptor in the bladder spasm subgroup was lower than that in the non-spasm subgroup. Conclusions There is a correlation between bladder spasm after prostate surgery and density of M3 muscarinic receptor in bladder mucosa, suggesting M3 receptor may be involved in the pathogenesis of bladder spasm and it can be used as a target to design drugs for prevention and control of bladder spasm.