慢性喘息型支气管炎与支气管哮喘患者的呼出气一氧化氮检测对比研究

Comparason of exhaled nitric oxide in patients with chronic asthmatic bronchitis and asthma

摘要:

目的  探讨呼出气一氧化氮（FeNO）检测在慢性喘息型支气管炎（以下简称慢喘支）和支气管哮喘（以下简称哮喘）两种疾病急性发作时的水平及意义。方法  随机选取就诊于该院呼吸内科门诊的慢喘支急性发作患者52例（慢喘支组）和哮喘急性发作患者48例（哮喘组），采用一氧化氮检测仪检测所有患者的FeNO水平，同时检测外周血嗜酸性粒细胞比率（EOS%）及肺功能等指标并进行分析。结果  慢喘支组FeNO水平和EOS%低于哮喘组，差异有统计学意义（P <0.01）；慢喘支组各项肺功能指标优于哮喘组，差异有统计学意义（P <
0.01）；慢喘支组FeNO水平与肺功能各项指标、EOS%无关（P >0.05）；哮喘组FeNO水平与肺功能各项指标无关（P >0.05），但与EOS%呈正相关（r =0.626，P <0.01）。结论  FeNO、EOS%及肺功能等指标可为慢喘支和哮喘两种疾病急性发作时的鉴别提供一定参考。

Abstract:

Objective To investigate the level of fractional exhaled nitric oxide (FeNO) and its significance in patients with chronic asthmatic bronchitis or asthma during acute exacerbations. Methods A total of 100 outpatients, including 52 cases with acute exacerbation of chronic asthmatic bronchitis and 48 cases with acute exacerbation of asthma, were recruited from the Department of Respiratory Medicine in our hospital. FeNO level was measured using nitric oxide analyzer, and peripheral eosinophil ratios (EOS%) and lung functions were also detected at the same time. Comparative study was conducted for all the data obtained. Results FeNO level and EOS% in the chronic asthmatic bronchitis patients were significantly lower than those in the asthma patients (P < 0.01). Pulmonary function parameters in the chronic asthmatic bronchitis patients were significantly better than those in the asthma patients (P < 0.01). FeNO had no correlation with lung function parameters or EOS% in the chronic asthmatic bronchitis patients (P > 0.05). There was no correlation between FeNO and lung function parameters in the asthma patients (P > 0.05), however, there was a positive correlation between FeNO and EOS% (r = 0.626, P < 0.01). Conclusions FeNO, EOS% and lung function indexes may be used for distinguishing acute exacerbation of chronic asthmatic bronchitis from that of asthma.