2型糖尿病伴干眼症患者泪液和血清白细胞介素6的变化

Expression of interleukin-6 in tears of type 2 diabetic patients with xerophthalmia

摘要:

目的  探讨2型糖尿病伴干眼症患者泪液、血清中白细胞介素6（IL-6）浓度的变化。方法  纳入人群分为3组：A组为2型糖尿病不伴干眼症患者组，B组为2型糖尿病伴干眼症患者组，C组为正常对照组。用ELISA法分别检测3组人群泪液、血清中IL-6的含量。采用单因素方差分析进行数据之间比较。并对泪液、血清IL-6进行相关性分析。结果  A、B和C组泪液IL-6含量分别为：（12.90±8.30）pg/ml、（22.43±12.97）pg/ml和（4.69±3.29）pg/ml，血清IL-6含量分别为（144.85±57.52）pg/ml、（256.26±117.96）pg/ml和（97.01±51.60）pg/ml。其中A组与B组血清及泪液IL-6含量均较C组高，B组血清及泪液IL-6含量较A组高（P <0.01）；泪液IL-6与血清IL-6水平呈正相关（r=0.73，P <0.01）。结论  2型糖尿病不伴干眼症患者泪液、血清IL-6含量均较正常健康人群增高，2型糖尿病伴干眼症患者泪液、血清IL-6水平进一步升高，提示泪液、血清IL-6水平与2型糖尿病伴干眼症的发生有关。泪液IL-6与血清IL-6水平呈直线正相关，提示泪液IL-6水平监测对于糖尿病并发干眼症患者的病情监测有一定的临床价值。

Abstract:

Objective To detect the concentration of the interleukin-6 (IL-6) in tears and serums of type 2 diabetic patients with xerophthalmia. Methods Patients were divided into: Group A (type 2 diabetes mellitus), Group B (type 2 diabetes mellitus with xerophthalmia) and Group C (normal). The concentrations of IL-6 in tear and serum were detected by ELISA. Comparisons between groups were tested by One-Way ANOVA analysis. Results Concentrations of tear IL-6 were (12.90 ± 8.30) pg/ml in group A, (22.43 ± 12.97) pg/ml in group B and (4.69 ± 3.29) pg/ml in group C. The concentrations of IL-6 in group A and group B were significantly higher than that in group C (P < 0.01). The concentration of IL-6 in group B was significantly higher than that in group A (P < 0.01). The level of tear IL-6 had positive correlation with the level of serum IL-6 (r = 0.73, P < 0.01). Conclusions The IL-6 concentration of tear in diabetic patients with xerophthalmia is elevated, which indicates that tear IL-6 and serum IL-6 are related to the occurrence of type 2 diabetes mellitus with xerophthalmia. Tear IL-6 level is positively related to serum IL-6 level, which indicates that tear IL-6 is useful in the surveillance of 2 diabetes mellitus with xerophthalmia.