吸烟降低男性2型糖尿病患者抗凝血酶Ⅲ活性

Smoking decreases activity of antithrombin Ⅲ in male patients with type 2 diabetes

摘要:

目的  探讨吸烟对男性2型糖尿病患者血浆抗凝血酶Ⅲ活性的影响。方法  选择男性2型糖尿病患者222例，根据吸烟指数分为不吸烟组（83例）、少量吸烟组（80例）和大量吸烟组（59例）。比较各组间基本临床资料及血浆抗凝血酶Ⅲ活性。结果  不吸烟组血浆抗凝血酶Ⅲ活性为（108.52±7.50）%，少量吸烟组为（105.30±8.88）%，大量吸烟组为（102.01±8.61）%。3组间血浆抗凝血酶Ⅲ活性呈逐渐降低趋势，差异有统计学意义（P <
0.01）。不吸烟组与少量吸烟组比较，差异有统计学意义（P =0.014）；不吸烟组与大量吸烟组比较，差异有统计学意义（P <0.01）；少量吸烟组与大量吸烟组比较，差异有统计学意义（P =0.022）。吸烟患者的吸烟指数与血浆抗凝血酶Ⅲ活性呈负相关（r =-0.30，P <0.01）。结论  吸烟可导致男性2型糖尿病患者血浆抗凝血酶Ⅲ活性降低。

Abstract:

Objective To investigate the effect of smoking on the activity of antithrombin Ⅲ in male patients with type 2 diabetes. Methods A total of 222 male patients with type 2 diabetes were chosen from the clinic. They were divided into 3 groups according to their smoking indexes: nonsmoker group (n = 83), mild-smoker group (n = 80) and heavy-smoker group (n = 59). The clinical characteristics and the activity of antithrombin Ⅲ were measured and compared. Results The activity of antithrombin Ⅲ was (108.52 ± 7.50)% in the nonsmoker group, (105.30 ± 8.88)% in the mild-smoker group, and (102.01 ± 8.61)% in the heavy-smoker group. There was a decreasing trend of antithrombin Ⅲ activity from the nonsmoker group, the mild-smoker group, to the heavy-smoker group with significant differences among the three groups (P < 0.05). The smoking index was negatively correlated with the activity of antithrombin Ⅲ in the smokers (r ＝ -0.30, P < 0.01). Conclusions Smoking might reduce the activity of antithrombin Ⅲ in male patients with type 2 diabetes.