定心汤对心律失常大鼠模型的影响

Effect of Dingxin decoction on arrhythmia in rat model

摘要:

目的  研究定心汤对心律失常大鼠模型的作用及各项相关指标的影响。方法  采用乌头碱所致心律失常模型观察药物作用。结果  定心汤对乌头碱致大鼠室性心律失常模型有明显作用，缩短心律失常持续时间，降低血清丙二醛（MDA）含量，增加血清超氧化物歧化酶（SOD）活性，增加心肌组织中Na+-K+-ATP酶、Ca2+-ATP酶活性。结论  定心汤有明显的抗室性心律失常作用，且呈剂量依赖性。

Abstract:

Objective To study the effect of Dingxin decoction on arrhythmia rat model and related indicators. Methods Aconitine-induced arrhythmia model was used to observe drug effects. Results Dingxin decoction had obvious effects on ventricular arrhythmia rat model caused by aconitine, which included shorter arrhythmia duration, lower serum malondialdehyde (MDA) content, increased the serum superoxide dismutase (SOD) activity, and increased Na+-K+-ATPase and Ca2+-ATPase activity in the myocardial tissue. Conclusions Dingxin decoction has significant anti-ventricular arrhythmia effects in a dose-dependent manner.