慢性阻塞性肺疾病患者旁正中丘脑氢质子磁共振波谱分析研究

A proton magnetic resonance spectroscopy imaging study on paramedian thalamus in patients with chronic obstructive pulmonary disease

摘要:

目的  研究慢性阻塞性肺疾病（COPD）患者旁正中丘脑氢质子磁共振波谱（1H-MRS）的特点。方法  随机选取2012年2月-2015年1月在该院就诊的32例COPD患者和30例健康志愿者分别纳入研究组和对照组。采用1H-MRS检测双侧旁正中丘脑的N-乙酰基天门冬氨酸（NAA）、胆碱复合物（Cho）和肌酸复合物（Cr）。结果  研究组双侧旁正中丘脑NAA/Cr值低于对照组，差异有统计学意义（P <0.05）；研究组双侧旁正中丘脑Cho/Cr值高于对照组，差异有统计学意义（P <0.05）。结论  COPD患者存在旁正中丘脑神经元的代谢异常。

Abstract:

Objective To identify the metabolite levels on paramedian thalamus in patients with COPD by proton magnetic resonance spectroscopy (1H-MRS). Methods Thirty-two patients with COPD in our hospital from February 2012 to January 2015 were randomly selected and 30 normal controls were also selected. 1H-MRS was used to detect N-acetyl aspartate (NAA), choline complex (Cho) and creatine complex (Cr) in paramedian thalamus of all the subjects. The ratios of NAA/Cr and Cho/Cr were determined. Results The NAA/Cr ratio in the bilateral paramedian thalamus of the patients with COPD was significantly lower than that in the normal controls (P < 0.05). The Cho/Cr ratio in the patients with COPD was higher than that in the normal controls, the difference was statistically significant (P < 0.05). Conclusions Metabolisms of neurons in paramedian thalamus are abnormal in patients with COPD.