子宫颈癌与纤维蛋白原基因多态性的相关性研究

Correlation between occurrence of cervical cancer and genetic polymorphisms of Fgβ-448G/A

摘要:

目的  探究在子宫颈癌发病过程中与纤维蛋白原（Fg）β448 G/A基因多态性的相关性。方法  采用聚合酶链反应-限制性片断长度多态性分析的方法对2013年5月-2014年12月初次就诊的汉族子宫颈癌患者141例标本与同期收集的健康汉族女性体检者141例标本的Fgβ448 G/A基因多态性进行基因型分型检测，并对检测结果进行统计分析。结果  ①病例组Fgβ448 G/A基因型频率及等位基因频率与对照组比较，病例组高于对照组（P <0.05）；②A等位基因与子宫颈癌的发生密切相关，③子宫颈癌GG、GA及AA基因型的血浆Fg水平分别是（3.09±0.22）、（3.11±0.26）和（3.31±0.51）g/L，差异无统计学意义（P >0.05）。结论  Fgβ448 G/A基因多态性变化与宫颈癌的发生可能具有相关性。

Abstract:

Objective To detect the relationship between cervical cancer and gene polymorphisms of β-fibrinogen gene (Fgβ)-448G/A. Methods Polymorphisms of Fgβ-448G/A gene were detected and analyzed in the specimens from 141 cervical cancer patients and 141 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method. Results The genotype frequency and allele frequency of Fgβ-448G/A in the cervical cancer group were significantly higher than those in the control group (P < 0.05). The allele A was closely associated with the incidence of cervical cancer. The plasma Fg levels in the cervical cancer patients with the genotypes GG, GA and AA were (3.09 ± 0.22) g/L, (3.11 ± 0.26) g/L and (3.31 ± 0.51) g/L respectively without obvious differences (P > 0.05). Conclusions The gene polymorphism of Fgβ-448G/A is possibly associated with the incidence of cervical cancer.