女性不孕症患者血清及宫颈黏液中自身抗体检测对病情的评估价值

Evaluation of autoantibodies in serum and cervical mucus of female infertility patients

摘要:

目的  分析女性不孕症患者血清及宫颈黏液中自身抗体检测对病情的评估价值。方法  选取2012年7月-2014年7月间至该院接受检查的女性不孕患者138例作为观察组对象。另取同期在该院因宫颈炎症接受检查的已育女性106例作为对照组。比较两组研究对象的血清及宫颈黏液自身抗体水平、外周血调解性T细胞（Treg）水平，进一步分析观察组患者中自身抗体与Treg水平的相关性。结果  ①观察组患者的血清及宫颈黏液中抗精子抗体（AsAb）、抗卵巢抗体（AoAb）、抗人绒毛膜促性腺激素（AhCGAb）、抗子宫内膜抗体（EMAb）、甲状腺自身抗体（ATA）、抗-β-2糖蛋白1抗体（α-β-2GP1）水平高于对照组女性（P <0.05）；②观察组患者的外周血Treg水平低于对照组（P <0.05）；③不孕症女性血清及宫颈黏液中的AsAb、AoAb、AhCGAb、EMAb、ATA、α-β-2GP1等自身抗体水平与外周血Treg水平呈负相关（P <0.05）。结论  女性不孕症患者血清及宫颈黏液中自身抗体水平大幅上升，与患者的疾病发生发展以及病情严重程度均关系密切，是临床诊断及指导治疗的理想指标。

Abstract:

Objective To analyze the assessed value of autoantibodies in female infertility patients' serum and cervical mucus. Methods Totally 138 cases of female infertility patients in our hospital between July 2012 and July 2014 were chosen as observation group, at same time 106 cases of female with cervix inflammation were chosen as control group. Serum and cervical mucus levels of autoantibodies and peripheral Treg level were compared between the two groups. The relationships between the autoantibodies with Treg level in the observation group were further analyzed. Results The serum and cervical mucus levels of AsAb, AoAb, AhCGAb, EMAb, ATA and α-β-2GP1 in the observation group were significantly higher than those in the control group (P < 0.05). The peripheral Treg level in the observation group was significantly lower than that in the control group (P < 0.05). In the observation group, serum and cervical mucus levels of AsAb, AoAb, AhCGAb, EMAb, ATA, α-β-2GP1 were inversely related with peripheral blood Treg level (P < 0.05). Conclusions In infertile females, serum and cervical mucus levels of antibodies significant increase, which are closely related to the development and severity of th disease, and are ideal indicators for clinical diagnosis and treatment guidance.