氩氦刀治疗对肝癌患者癌细胞恶性生物学行为的影响

Effect of argon-helium cryoablation on malignant biological behavior of cancer cells in liver cancer patients

摘要:

目的  分析氩氦刀治疗对肝癌患者癌细胞恶性生物学行为的影响。方法  选取2013年7月-2014年7月于该院接受治疗的肝癌患者88例作为研究对象。按照随机数字表法将所有入组患者分为观察组及对照组各44例，对照组患者接受单纯肝动脉化疗栓塞（TACE）治疗，观察组患者接受TACE联合氩氦刀治疗。比较两组患者的治疗后血清血管新生相关指标、侵袭相关指标、肿瘤预后相关指标等水平差异。结果  观察组患者的治疗后血清内皮生长因子（VEGF）、缺氧诱导因子-α（HIF-1α）、层黏连蛋白（Lam）水平值低于对照组患者，差异有统计学意义（P <0.05）；观察组患者接受治疗后的血清细胞间黏附分子-1（ICAM-1）、内皮细胞特异性分子-1（ESM-1）、基质金属蛋白酶-13（MMP-13）、尿激酶型纤溶酶原激活物（uPA）水平均低于对照组患者，差异有统计学意义（P <0.05）；观察组患者的治疗后甲胎蛋白（AFP）、癌胚抗原（CEA）、a-L-岩藻糖苷酶（AFU）、可溶性B7-H3（sB7-H3）水平低于对照组患者，差异有统计学意义（P <0.05）。结论  肝癌患者接受氩氦刀治疗，可以降低肿瘤细胞的恶性生物学行为，有助于治疗效果的实现以治疗预后的改善，具有积极的临床意义。

Abstract:

Objective To analyze the effect of argon-helium cryoablation on cancer cell biological behavior in liver cancer patients. Methods A total of 88 cases of liver cancer patients in our hospital between July 2013 and July 2014 were chosen as research subjects and divided into observation group and control group according to random number table method, each group had 44 patients. The patients in the ontrol group received transarterial chemoembolization (TACE) alone, while the patients in the observation group received TACE and argon-helium cryoablation. Serum angiogenesis-related indicators, invasion related indicators and tumor prognostic indicators were compared between the two groups. Results Serum VEGF, HIF-1α and Lam levels in the observation group were significantly lower than those in the control group (P < 0.05). Serum ICAM-1, ESM-1, MMP-13 and uPA levels in the observation group were significantly lower than those in the control group (P < 0.05). AFP, CEA, AFU and sB7-H3 levels in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). Conclusions Argon-helium cryoablation treatment can reduce the malignant behavior of tumor cells in patients with liver cancer, is helpful to achieve a better therapeutic effect and improve the prognosis, and has positive clinical significance.