点阵铒激光联合氟米松软膏治疗结节性痒疹的短期疗效观察

Clinical efficacy of dot matrix erbium laser conbining flumetasone paste for treatment of prurigo nodularis

摘要:

目的  评价点阵铒激光联合氟米松治疗结节性痒疹的临床疗效。方法  将结节性痒疹患者42例随机分成两组，治疗组使用波长2 940 nm铒激光治疗仪，采用微剥脱+点阵模式及两种方法联合氟米松软膏治疗；对照组给予复方氟米松软膏外擦治疗，疗程4周。结果  治疗2周、4周的两组患者有效率差异均无统计学意义，但治疗组患者的痊愈+显效率明显高于对照组（2周：18/21 vs 3/21；4周：19/21 vs 6/21）。此外，治疗2周后，治疗组瘙痒VAS评分明显低于对照组[（4.34±1.81）vs（6.72±2.19），t =5.311，P =0.032]；治疗4周后，治疗组瘙痒VAS评分明显低于对照组[（2.61±1.40）vs（5.19±1.66），t =4.881，P =0.029]。结论  铒激光联合氟米松乳膏治疗结节性痒疹的短期疗效显著，可有效缓解症状。

Abstract:

Objective To evaluate the clinical efficacy of dot matrix erbium laser conbining with compound recipe flumetasone paste for the treatment of nodular prurigo. Methods A total of 42 patients with prurigo nodularis were randomly divided into two groups, with the name of treatment group (n = 21, dot matrix erbium laser conbining with compound recipe flumetasone paste) and control group (n = 21 flumetasone paste only). The course of treatment was four weeks. Results The effective power in treatment group and control group showed no difference on 2 and 4 weeks during treatment. However, the rate of heal and excellence showed a higher level in the treatment group than those of in the control group. In addition, the VAS score for pruritus showed a higher score in the treatment group than those of in the control group as well. Conclusions The short-term efficacy of prurigo nodularis with dot matrix erbium laser conbining flumetasone paste is distinct and can effectively relieve symptoms.