缺血性脑卒中与血清叶酸的相关性研究

Association of serum folic acid with ischemic stroke

摘要:

目的  探讨血清叶酸水平与缺血性脑卒中的关系，检测和比较病例组和对照组血清叶酸水平。方法  本研究是2013年7月-2013年12月在河南省人民医院进行的一项病例对照研究。60例缺血性脑卒中患者和60例健康受试者纳入本次研究。所有缺血性脑卒中患者，年龄均在20岁及以上，发病时间从24h～30d，经脑CT/头部MRI扫描证实。收集病例组和对照组血液样本，检测空腹血糖血清叶酸和血清同型半胱氨酸含量。结果  病例组中45例（75%）为男性，15例（25%）为女性，年龄均值为（58.42±11.47）岁。对照组男性和女性分别为43例（71.7%）和17例（28.3%）。病例组和对照组血清叶酸水平分别为（6.26±4.06）和（8.07±4.70）。观察到病例组与对照组血清叶酸项之间的差异有统计学意义（P <0.05）。本研究表明，在缺血性卒中的早期阶段，血清叶酸水平不足。结论  低血清叶酸浓度与缺血性脑卒中风险增加存在显著性和独立性。

Abstract:

Objective To evaluate the association of serum folic acid level with ischemic stroke and to measure and compare the serum folic acid level among the cases and control subjects. Methods This study was a case-control study which was conducted in the Department of Neurology, People's Hospital of Henan between July 2013 and December 2013. A total of 60 patients presented with ischemic stroke and 60 control people were enrolled in this study. The patients with ischemic stroke aged 20 years and over. The onset time was from 24 h to 30 d. The disease was confirmed by CT scan of head or MRI of brain. Blood samples were collected from the cases and the controls, and serum folic acid, serum homocysteine and fasting blood sugar were analyzed. Results The mean age of the cases was (58.42 ± 11.47) y and among the cases 45 (75.0%) were male and 15 (25.0%) were female. Among the controls male and female were 43 (71.7%) and 17 (28.3%) respectively. The mean serum folate level of the case group and the control group was (6.26 ± 4.06) and (8.07 ± 4.70) respectively. Statistically significant difference was observed in serum folate between the case group and the control group (P < 0.05). This study showed serum folate level was deficient at the early period of ischemic stroke. Conclusions Low serum folate concentration is significantly associated with increased risk for ischemic stroke.