急性心力衰竭患者联合检测血清糖类抗原CA125和N末端脑钠肽原的临床意义

Prognostic value of carbohydrate antigen-125 and N-terminal pro-brain natriuretic peptide levels in patients with acute heart failure

摘要:

目的  对联合检测血清糖类抗原CA125（CA125）和N末端脑钠肽原（NT-proBNP）水平用于预测急性心力衰竭患者预后的价值进行评估。方法  纳入68例急性左心衰竭发作24 h之内入院的患者，检测血清NT-proBNP和CA125水平，根据患者出院6个月时的预后，分为死亡（6个月之内死亡）、再发作（存活，有急性左心衰竭再发作）和稳定（存活且无心力衰竭再发作）组，对单独和联合应用NT-proBNP和CA125水平用于预测患者预后的价值进行分析。结果  不同分组患者的CA125水平差异有统计学意义（P =0.013），再发作组和死亡组患者的血清CA125水平高于稳定组，差异有统计学意义（P =0.004和0.030），CA125和NT-proBNP均为阳性者的死亡风险高于其他患者。结论  联合检测血清CA125和NT-proBNP水平，可以准确预测急性心力衰竭患者出院6个月之内的死亡风险。

Abstract:

Objective To evaluate the prognostic value of serum carbohydrate antigen-125 (CA125) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with acute heart failure. Methods Sixty-eight patients with acute left heart failure were included and divided into three groups according to different prognosis six months after discharge: dead (dead during 6 months), recurred (alive with recurred acute left heart failure) and stable (alive without recurred acute left heart failure) groups. The prognostic value of serum NT-proBNP and CA125 levels alone and in combination were analysed. Results The serum CA125 levels were significantly different between different groups (P = 0.013), and the levels were significantly increased in recurred and dead groups compared with stable group (P = 0.004 and 0.030, respectively). The mortality risk during 6 months after discharge was significantly higher in patients with positive CA125 and NT-proBNP compared with other patients. Conclusions The combination of CA125 and NT-proBNP levels could accurately predict the mortality risk in patients with acute heart failure during six months after discharge.