Abstract:Objective To compare the early effect of the primary total knee arthroplasty (TKA) with different design concepts of knee prosthesis. Methods From January 2012 to December 2014, a total of 250 patients (250 knees) with knee osteoarthritis (OA) was operated TKA, with 70 male and 180 female. The knee prosthesis of patients was one of LINK Gemini MK Ⅱ, Smith-Nephew Genesis Ⅱ and Biomet Vanguard. The American association of knee scoring system (including the clinical scores and function scores) was used to examine the surgical effect for the follow-up, and the average time of follow-up was 1.5 years (1 - 3 years). Results The total of 216 cases was completed the follow-up (86.4%). The knee clinical scores of LINK Gemini MK Ⅱ, Smith-Nephew Genesis Ⅱ and Biomet Vanguard postoperative had no significant difference (P > 0.05), and the functional scores had significant differences (P <0.05). The patients of Smith-Nephew Genesis II and Biomet Vanguard had better knee functions in the early follow-up. Conclusions All three kinds of knee prosthesis in the primary knee arthroplasty can provide good surgical effect on patients, and the prosthesis of Smith Nephew Genesis Ⅱ and Biomet Vanguard provide better restore function.