冠状动脉粥样硬化性心脏病合并心力衰竭患者血浆Ω-3脂肪酸、超敏C反应蛋白水平及意义

Clinical significance of levels of Ω-3 fatty acids, hs-CRP in patients with coronary heart disease and heart failure

摘要:

目的  探讨冠状动脉粥样硬化性心脏病（以下简称冠心病）并心力衰竭（以下简称心衰）患者血浆Ω-3脂肪酸、hs-CRP的水平及意义。方法  选取2012年3月-2014年12月在河南科技大学第一附属医院住院的冠心病并心衰患者43例（A组），同时期住院行冠状动脉造影确诊为冠心病的患者55例（B组），随机选取同时期健康体检者40例（C组）。对比检测健康体检者、冠心病患者、冠心病并心衰患者的血浆Ω-3脂肪酸、hs-CRP水平，并分析冠心病并心衰患者血浆Ω-3脂肪酸、hs-CRP水平的相关性。结果  A组血浆Ω-3脂肪酸水平低于B、C组，B组血浆Ω-3脂肪酸水平低于C组，组间比较，差异有统计学意义（P <0.05）。A组hs-CRP高于B、C组，B组hs-CRP高于C组，组间比较，差异有统计学意义（P <0.05）。冠心病患者及冠心病并心衰患者的血浆Ω-3脂肪酸、hs-CRP水平等指标的相关性回归分析表明，hs-CRP与血浆Ω-3脂肪酸水平呈负相关，变化趋势具有一致性，两者比较，差异有统计学意义（r =-0.976，P <0.05）。结论  血浆Ω-3脂肪酸、hs-CRP水平与冠心病患者病情程度有关。

关键词:

&Omega;-3脂肪酸;hs-CRP;冠状动脉粥样硬化性心脏病;心力衰竭

Abstract:

Objective To investigate the serum levels of Ω-3 fatty acid and hs-CRP and their clinical significance in heart failure patients with coronary heart disease (CHD). Methods Forty-three heart failure patients with CHD who were hospitalized at First Affiliated Hospital of Henan University of Science and Technology were assigned to group A, while 55 with diagnosed CHD who were concurrently hospitalized and underwent coronary angiography were assigned to group B, and 40 concurrent healthy subjects were assigned to group C. Serum levels of Ω-3 fatty acid and hs-CRP were detected in the three groups, and the correlation between serum levels of Ω-3 fatty acid and hs-CRP was analyzed. Results Serum level of Ω-3 fatty acid in group A was lower than that in groups B and C, while group B was lower than group C, and differences were statistically significant (P < 0.05). Levels of hs-CRP in group A were higher than groups B and C, while group B was higher than group C, and differences were statistically significant (P < 0.05). Correlation analyses of serum levels of Ω-3 fatty acid and hs-CRP in CHD patients and heart failure patients with CHD indicated a negative correlation between hs-CRP and serum Ω-3 fatty acid level, and had a consistent trend, and statistically significant difference (r = -0.976, P < 0.05). Conclusion Serum levels of Ω-3 fatty acid and hs-CRP were correlated with the severity of CHD.

Key words:

&Omega;-3 fatty acids; hs-CRP; coronary heart disease; heart failure