Abstract:Objective To investigate the treatment effect of aspirin and clopidogrel dual antiplatelet therapy combined with butylphthalide and sodium chloride injection on sleep disorders in patients with progressive cerebral infarction and the influence on sleep structure, and to providing the basis for reducing the progressive risk of cerebral infarction. Methods A total of 206 patients who were hospitalized in the department of Neurology of the Second Hospital of Baoding from April 2013 to December 2015 were sampled in accordance with the progressive cerebral infarction associated with sleep disorder. The samples were randomly divided into treatment group including 103 cases (treated with butylphthalide and sodium chloride injection) and control group with another 103 cases without treatment. The onset time of the patients was within 48 hours, PSQI ≥ 8. Grading for PSQI, NIHSS, Barthel scores were recoeded before the treatment, and after the treatment on the day 8, 15 and 30. All patients were monitored through polysomnography on the day 1 and 30. All the data including PSQI, NIHSS, Barthel scores, sleep structure and process index were recorded, compared and analyzed. Results There were significant differences (P < 0.05) between the treatment group on day 15 and day 30 after treatment. Compared with the control group, and with the same group before treatment, the PSQI, NIHSS score and Barthel score in the treatment group had significant differences (P < 0.05). After the 30-day treatment, compared with the control group, the total sleep time, sleep efficiency, deep sleep ratio, and the ratio of REM phase were all significantly increased. The sleep latency, sleep apnea, nighttime awakenings and the apnea hypopnea index (P < 0.05) were significantly decreased in the treatment group. Conclusions Butylphthalide and sodium chloride injection combined together with aspirin and clopidogrel can effectively intervene in the progress of sleep disorder after cerebral infarction and improve the sleep structure.
