锌指蛋白217在结肠癌组织中的表达及其临床意义

Expression and clinical significance of ZNF217 in colon cancer

摘要:

目的  检测锌指蛋白217（ZNF217）在结肠癌中的表达，分析ZNF217的表达水平与结肠癌患者临床病理特征及结肠癌患者生存与预后的相关性。方法  利用免疫组织化学方法检测84例结肠癌患者组织标本及相应癌旁组织中ZNF217的表达水平，并利用Spearman秩相关、K-M曲线及Cox比例风险回归模型等统计方法分析ZNF217在结肠癌中的临床相关性。结果  免疫组化结果发现结肠癌组织中ZNF217阳性表达率高于癌旁组织。Spearman秩相关显示ZNF217的表达水平与结肠癌患者TNM分期和淋巴转移情况呈正相关，且与其他结肠癌患者临床病理特征无相关性。K-M曲线显示ZNF217表达水平与结肠癌患者术后总体生存率及无进展生存率呈负相关。Cox风险比例模型显示ZNF217可作为判断结肠癌预后独立的预测指标。结论  ZNF217在结肠癌组织中表达升高，且可作为判断结肠癌患者生存及预后的独立的潜在分子指标。

Abstract:

Objective To explore the expression of ZNF217 in tissues of colon cancer (CRC), investigate the association of the expression levels of ZNF217 and clinicopathological features of CRC patients, and analyze the relevance of ZNF217 and survival and prognosis of CRC patients. Methods Expressions of ZNF217 were analyzed by immunohistochemistry in 84 CRC patients. Spearman's rank test, K-M survival curves, and Cox proportional hazards risk were conducted to analyze the clinical relevance of ZNF217 in CRC. Results Immunohistochemistry revealed that the positive rate of ZNF217 was upregulated in CRC tissues compare with adjacent tissues. Spearman rank correlation showed that positive ZNF217 expression was significantly associated with TNM stage, lymph node status and venous invasion of CRC patients. Kaplan-Meier curves showed that positive ZNF217 expression was inversely correlated with 5 years overall and progression-free survival time of CRC patients. Cox proportional hazards risk analysis revealed that ZNF217 was an independent prognostic factor for CRC. Conclusions ZNF217 expression is upregulated in tissues of CRC, and ZNF217 is a potential survival and prognosis biomarker in CRC.