胶原膜联合β-磷酸三钙治疗颌骨囊肿术后骨缺损的疗效分析
作者:
作者单位:

1.浙江中医药大学口腔医学院,浙江 杭州 310000;2.中国人民解放军联勤保障部队 第903医院 血液科,浙江 杭州310013

作者简介:

通讯作者:

徐冬娥,E-mail:xde0571@qq.com

中图分类号:

R782

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Efficacy of collagen membrane combined with β-tricalcium phosphate in the treatment of jaw defects after cyst enucleation
Author:
Affiliation:

1.School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310000, China;2.Department of Hematology, The 903 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Hangzhou, Zhejiang 310013, China

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    摘要:

    目的 分析胶原膜联合β-磷酸三钙(β-TCP)治疗颌骨囊肿术后骨缺损的疗效。方法 选取2015年1月—2020年1月浙江中医药大学附属口腔医院收治的因牙源性颌骨囊肿行手术治疗的162例患者。根据修复骨缺损的不同方式分为3组,每组54例。A组:术后不放置任何材料;B组:术后使用胶原膜覆盖骨缺损部位;C组:术后使用β-TCP进行填塞,且使用胶原膜覆盖。术前及术后3个月、6个月、12个月所有患者行锥形束CT检查,测定其骨缺损区域的骨密度。结果 所有患者未复发。A组、B组与C组术前及术后3个月、6个月、12个月的CT值比较,采用重复测量设计的方差分析,结果 ①不同时间点CT值有差异(F =34.335,P =0.000);3组CT值均随时间增加不断升高(P <0.05)。②3组CT值有差异(F =9.634,P =0.008);A组最低(P <0.05),C组最高(P <0.05)。③3组CT值变化趋势有差异(F =165.591,P =0.000)。结论 胶原膜联合β-TCP治疗颌骨囊肿术后骨缺损的成骨效果较好,值得临床推广应用。

    Abstract:

    Objective To explore the efficacy of collagen membrane combined with β-tricalcium phosphate (β-TCP) in the treatment of jaw defects after cyst enucleation.Methods A total of 162 patients with odontogenic jaw cysts undergoing surgical treatments in Stomatology Hospital Affiliated to Zhejiang Chinese Medical University from January 2015 to January 2020 were selected, and they were divided into 3 groups according to the random number table method, with 54 cases in each group. Group A did not receive any filling materials after surgery. The collagen membrane was applied to cover the jaw defects after surgery in group B. In contrast, the bone defects were filled with β-TCP and covered with collagen membrane after surgery in group C. All patients underwent cone-beam CT (CBCT) before the operation and 3, 6, and 12 months after the operation to determine the bone mineral density of the defect areas.Results None of the patients relapsed after the surgery. The repeated measurement of CT value via CBCT in the three groups before the operation and 3, 6, and 12 months after the operation demonstrated that there were differences in the CT value of the groups at distinct time points (F =34.335, P =0.000), and that the CT value increased over time (P < 0.05). The CT value was also different among the three groups (F =9.634, P =0.008), and was highest in the group C (P < 0.05) but lowest in the group A (P < 0.05). In addition, the change trend of CT value was different among the groups (F =165.591, P =0.000).Conclusions The collagen membrane combined with β-TCP is effective in promoting the bone formation for jaw defects after cyst enucleation, and is therefore of great value in clinical practice.

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刘敏,徐冬娥.胶原膜联合β-磷酸三钙治疗颌骨囊肿术后骨缺损的疗效分析[J].中国现代医学杂志,2022,(4):35-39

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  • 收稿日期:2021-09-11
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  • 在线发布日期: 2023-10-30
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