间充质干细胞外泌体抑制创伤性脑损伤炎症反应的研究进展
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遵义医科大学附属医院急诊科

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R394.2

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国家自然科学基金(81760233);省部共建协同创新中心项目(教科技厅函[2020]39号);黔科合平人才项目[(2017)5733-020];贵州省教育厅自然科学研究项目(GZZ2017006)


Research progress of mesenchymal stem cell exosomes inhibiting inflammatory response in traumatic brain injury
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    摘要:

    中国每年约有80万左右的新发创伤性脑损伤(TBI)患者,其中重度TBI患者死亡率约为27%,是青壮年死亡和致残的首要原因,为社会及家庭带来极大影响。TBI按病理生理机制分为原发性脑损伤和继发性脑损伤。原发性脑损伤是机械性致伤因素的直接结果,而继发性脑损伤是在原有脑损伤基础上,颅外损伤与颅内物理、生化变化的总和,与TBI预后有重要关系。其中神经炎症反应所引起的一系列分子、细胞、组织器官水平级联反应在继发性脑损伤形成有重要作用。间充质干细胞外泌体(MSCs-Exo)作为目前脑损伤极具前景的治疗方式,可有效减轻神经炎症反应,并改善TBI预后,本文综述间充质干细胞外泌体在TBI后抑制神经炎症反应的作用机制及其治疗前景,以期为后续的研究和治疗提供一定的参考。

    Abstract:

    There are about 800,000 patients suffering from traumatic brain injury (TBI) in China each year. The mortality rate of patients with severe TBI is about 27%. It is the leading cause of death and disability among young adults and has a great impact on society and families. TBI is divided into primary brain injury and secondary brain injury according to the pathophysiological mechanism. Primary brain injury is a direct result of mechanical injury factors, while secondary brain injury is based on the original brain injury. At the same time, the sum of extracranial injury and intracranial physical and biochemical changes has an important relationship with the prognosis of TBI. And a series of molecular, cell, tissue and organ level cascade reactions caused by neuroinflammatory reaction play an important role in the formation of secondary brain injury. Mesenchymal stem cell exosomes (MSCs-Exo), as a promising treatment for brain injury, can effectively reduce neuroinflammatory response and improve the prognosis of TBI. This article reviews the inhibition of neuroinflammation by mesenchymal stem cell exosomes after TBI. The mechanism of reaction and its treatment prospects are expected to provide a certain reference for follow-up research and treatment.

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  • 收稿日期:2021-07-08
  • 最后修改日期:2021-07-08
  • 录用日期:2021-08-01
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