制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病的疗效及安全性分析

The efficacy and safety of nystatin combined with antimicrobial photodynamic therapy on oral candidiasis

摘要:

目的 探讨制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病的疗效及安全性。方法 选取2018年3月—2020年4月新疆医科大学第五附属医院口腔科收治的86例口腔念珠菌病患者，按照随机分组方法分为对照组和研究组，每组43例。对照组接受制霉菌素口服50万u/次，3次/d，研究组在对照组基础上联合光动力抗菌疗法，每隔24 h光疗1次，均治疗1周。对比两组临床疗效、安全性、治疗前后念珠菌菌数、复发率。结果 研究组总有效率高于对照组（P <0.05）。治疗前两组念珠菌菌数比较，差异无统计学意义（P >0.05）；治疗后研究组念珠菌菌数低于对照组（P <0.05）。治疗后两组念珠菌菌数均低于治疗前（P <0.05）。研究组复发率低于对照组（P <0.05）。两组治疗期间不良反应发生率比较，差异无统计学意义（P >0.05）。结论 制霉菌素联合光动力抗菌疗法治疗口腔念珠菌病疗效显著，可降低复发率及念珠菌菌数，且安全可靠。

Abstract:

Objective To investigate the efficacy and safety of nystatin combined with antimicrobial photodynamic therapy on oral candidiasis.Methods We selected 86 patients with oral candidiasis who were admitted to our department from March 2018 to April 2020, and they were randomly divided into two groups. The control group received 500,000 u of oral nystatin each time, 3 times a day. On the basis of the control groups, the research group was treated with antimicrobial photodynamic therapy which was performed every 24 hours for 1 week. The clinical efficacy, safety, the Candida count before and after the treatment, and the recurrence rate were compared between the groups.Results The overall effective rate was higher in the research group relative to the control group (P < 0.05). There was no difference in the Candida count between the two groups before treatment (P > 0.05). After treatment, the Candida count was lower in the research group (P < 0.05), though the Candida count after treatment was decreased in both groups compared with that prior to the treatment (P < 0.05). The recurrence rate of the research group was lower than that of the control group (P < 0.05). Additionally, there was no difference in the incidence of adverse reactions between the two groups during the treatment (P > 0.05).Conclusions Nystatin combined with antimicrobial photodynamic therapy is effective and safe in treating patients with oral candidiasis, by reducing the recurrence rate and the Candida count.