Abstract:Objective To explore the correlation between echocardiographic quantitative parameters and early weaning outcomes of mechanical circulatory support (MCS) in patients with acute myocardial infarction.Methods The data of 82 patients with acute myocardial infarction treated by MCS in the hospital from February 2020 to February 2022 were retrospectively analyzed, the Color Doppler ultrasound was used to measure the echocardiographic parameters of the patients after weaning and weaning, including left ventricular ejection fraction (LVEF), mitral sidewall annular systolic velocity (Sa), and right ventricular area fractional change (RVFAC) and left ventricular outflow tract velocity-time integral (LVOT-VTI), the 28-day survival of patients after weaning was counted. The difference of echocardiographic parameters after boarding and weaning between the dead patients and the surviving patients was compared. The factors affecting the outcome of early MCS weaning in patients with acute myocardial infarction were analyzed, the receiver operating curve (ROC) was used to analyze the value of the difference of echocardiographic parameters after boarding and weaning in predicting the outcome of early MCS weaning in patients with acute myocardial infarction.Results During the 28-day follow-up after weaning, 24 of the 82 patients with acute myocardial infarction died. The proportions of multiple organ failure and multi-vessel disease in the dead patients were higher than those in the surviving patients (P < 0.05). The difference of LVEF, Sa, RVFAC, and LVOT-VTI after boarding and weaning of the dead patients were lower than those of the surviving patients (P < 0.05). Logistic multivariate regression analysis showed that multiple organ failure [O^R = 3.367 (95% CI: 1.073, 10.562) ], LVEF [O^R = 3.327 (95% CI: 1.060, 10.436) ], Sa [O^R = 3.476 (95% CI: 1.108, 10.906) ], RVFAC [O^R =3.721 (95% CI: 1.186, 11.673) ], LVOT-VTI [O^R = 3.931 (95% CI: 1.253, 12.333) ] after boarding were the risk factors for death after early MCS weaning in patients with acute myocardial infarction (P < 0.05). ROC analysis showed that the best cut-off points of difference of LVEF, Sa, RVFAC, and LVOT-VTI after boarding and weaning were 22.18%, 5.01 cm/s, 26.87% and 9.93 cm, respectively, and the combined sensitivity, specificity and AUC were 79.17% (95% CI: 0.578, 0.929), 98.28% (95% CI: 0.908, 1.000), 0.927 (95% CI: 0.847, 0.973), respectively.Conclusion Quantitative echocardiographic parameters are associated with early MCS weaning outcomes in patients with acute myocardial infarction, and it can be used as a sensitive indicator for predicting patient mortality.