熊去氧胆酸联合甘草甜素片治疗妊娠期肝内胆汁淤积症的临床疗效

Effects of ursodeoxycholic acid combined with glycyrrhizin tablets on ICP and level of inflammatory reaction

摘要:

目的 探讨熊去氧胆酸联合甘草甜素片治疗妊娠期肝内胆汁淤积症（ICP）的临床疗效及对炎症因子的影响。方法 选取2016年6月—2017年12月在陕西中医药大学第二附属医院治疗的ICP孕妇120例作为研究对象，采用随机数字表法分为对照组和观察组，每组60例。对照组使用熊去氧胆酸；观察组在对照组基础上联合甘草甜素片治疗ICP。比较两组临床疗效、肝功能及炎症因子水平。结果 观察组总有效率高于对照组（P <0.05）。两组治疗后血清总胆汁酸、甘草酸、血清胆红素、直接胆红素、丙氨酸氨基转移酶及天门冬氨酸氨基转移酶水平均改善（P <0.05），且观察组优于对照组（P <0.05）。两组治疗后白细胞介素-12、肿瘤坏死因子-α表达水平下降，且观察组低于对照组（P <0.05）；观察组妊娠结局优于对照组（P <0.05）。结论 熊去氧胆酸联合甘草甜素片治疗ICP能够有效缓解患者临床症状，有效改善患者的肝功能并降低炎症反应水平。

Abstract:

Objective To investigate the effects of ursodeoxycholic acid combined with Glycyrrhizin Tablets on ICP and inflammation level.Methods From December 2016 to December 2017, 120 pregnant women with cholestasis during pregnancy and obstetrics were selected and divided into the control group and the observation group according to the random digital table method. Control group was treated with ursodeoxycholic acid, and the observation group administrated with Glycyrrhizin Tablets on the basis that. Clinical efficacy, liver function, and inflammatory factors of the two groups were compared.Results The clinical efficacy of the observation group was better than control group (P < 0.05). The levels of total bile acid, cholic acid, serum bilirubin, direct bilirubin, glutamic pyruvic aminotransferase, and gluten transaminase in the two groups were significantly improved (P < 0.05). And observation group displayed a better result (P < 0.05). The expression level of IL12 and TNF- α in the two groups was significantly decreased, and the decrease level of the observation group was more significant (P < 0.05). Additionally, observation group observed a better pregnancy outcome than control group (P < 0.05).Conclusion Ursodeoxycholic acid combined with glycyrrhizin tablets could release the clinical symptom of ICD, improve liver function, and reduce the inflammation level.