Ultrasound is widely used in clinical practice as imaging methodology and physiotherapy approach. Low-intensity focused ultrasound (LIFU) is emerging for its unique features and prospects in neuromodulation. In contrast to electric stimulation and magnetic neuromodulation methods, LIFU has the advantage of noninvasiveness, reversibility and accuracy, which expand our knowledge and its application in neuromodulation. This paper reviews the research progress of neuromodulation via low-intensity focused ultrasound.