骨关节炎疼痛相关危险因素研究进展

Research progress on pain related risk factors of osteoarthritis

摘要:

疼痛是骨关节炎最突出的症状，也是一种复杂、多因素的生理现象。该综述主要从影响疼痛的相关危险因素进行简要概述。疼痛不仅与关节结构损伤有关，遗传、环境（肥胖）、心理和神经等因素均具有重要作用。每一个因素可单独发挥其作用，也能与其他因素混合，从而导致复杂性疼痛，这可以部分解释目前现有治疗方法疗效均不佳的现象。确定骨关节炎疼痛的危险因素，有助于准确鉴定疼痛表型，为骨关节炎疼痛患者的个体化干预提供可能。该文对骨关节疼痛的相关危险因素的研究报道做一综述。

Abstract:

Pain is the most prominent symptom of osteoarthritis. Pain sensation is a complex and multifactorial physiological phenomenon. This review mainly summarizes the related risk factors that affect pain. Pain is not only related to joint structure damage, genetic, environmental (obesity), psychological and neurological factors have an important role. Each factor can act alone or be combined with other factors to create complex pain, which may partly explain why current treatments are ineffective. Determining the risk factors of osteoarthritis pain is helpful to accurately identify the pain phenotype and provide the possibility of individualized intervention for patients with osteoarthritis pain.