小而密低密度脂蛋白胆固醇对糖尿病足的影响

Clinical research of small dense low density lipoprotein and diabetic foot

摘要:

目的 分析2型糖尿病患者血清小而密低密度脂蛋白胆固醇（sdLDL-C）水平对糖尿病足的影响。方法 选取2018年6月—2019年6月在哈尔滨医科大学附属第一医院就诊的2型糖尿病患者213例，分为非糖尿病足组160例及糖尿病足组53例。收集患者基本临床资料，行生化检验及血清sdLDL-C检测，采用Logistic回归分析糖尿病足的相关危险因素。结果 糖尿病足组患者的收缩压（SBP）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）及sdLDL-C较非糖尿病足组升高（P <0.05），视网膜病变率及大血管并发症率较非糖尿病足组高（P <0.05），且糖尿病病程较长（P <0.05）。Logistic回归分析显示：FBG［O^R=3.302（95% CI：1.154，7.473）］、HbA1c［O^R=3.971（95% CI：1.982，6.131）］、sdLDL-C［O^R=5.996（95% CI：3.019，11.897）］是糖尿病足的危险因素。结论 血清sdLDL-C影响糖尿病足的发生、发展，可作为糖尿病足防治的潜在靶点。

Abstract:

Objective To assess the correlation between the serum level of small dense low density lipoprotein cholesterol (sdLDL-C) and diabetic foot in type 2 diabetes mellitus (T2DM).Methods From Jun 2018 to Jun 2019, 213 T2DM patients admitted in department of the first affiliated hospital of harbin medical university were included in this study. They were divided into non-diabetic foot group (160 cases) and diabetic foot group (53 cases). The basic clinical information, biochemical tests, and serum sdLDL-C were collected, and the risk factors of diabetes mellitus were analyzed by logistic regression.Results Compared with non-diabetic foot group, systolic blood pressure, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), and sdLDL-C in diabetic foot group increased significantly (P < 0.05), the risk of retinopathy and macrovascular complications were higher (P < 0.05), and the duration of diabetes was much longer (P < 0.05). Logistic regression analysis showed that FBG [O^R = 3.302 (95% CI: 1.154, 7.473)], HbA1c [O^R = 3.971 (95% CI: 1.982, 6.131)], and sdLDL-C [O^R = 5.996 (95% CI: 3.019, 11.897)] were risk factors for diabetic foot, and the level of sdLDL-C was positively related to the severity of diabetic foot.Conclusion Serum sdLDL-C is closely related to the occurrence and development of diabetic foot. It can be used as a potential target for prevention and treatment of diabetic foot.