循环肿瘤DNA的研究进展与应用前景

Research progress and application prospect of circulating tumor DNA

摘要:

随着医学的发展，对肿瘤的认识越来越深入，并在肿瘤诊疗中取得了不错的成绩。随着科技的进步，肿瘤精准诊疗成为了未来的趋势。目前常用的组织穿刺活检存在穿刺偏倚、创伤等问题，因此寻找一种高效的方法就成为研究的重点。循环肿瘤DNA（ctDNA）来源于肿瘤，能很好的反映肿瘤的基因信息，并且会随着肿瘤的进展发生相应的改变。近年来ctDNA其独特的能力备受人们关注并被广泛研究，该文就其研究进展与应用前景做一综述。

Abstract:

We have been getting a deeper and deeper understanding of tumor, and have made great progress in cancer diagnosis and treatment. With the advancement of technology, precise diagnosis and treatment of cancer will become a trend in the future. At present, tissue biopsy is widely used but there are still some problems such as sampling bias and that it is an invasive procedure. Thus, developing an efficient approach to detecting tumors has become the focus of relevant researches. It is found that circulating tumor DNA (ctDNA) is derived from tumors, reflects the genetic information of tumors well, and changes dynamically with the progression of tumor. In recent years, the distinctive role of ctDNA has attracted much attention and has been extensively studied. This article will review the research progress and application prospect of ctDNA.