Abstract:The number of patients with xerophthalmia is on the rise, and multiple factors, such as sex hormone levels, inflammatory response, diabetes mellitus, electronic devices, contact lenses, sleep quality and eye surgery, are potentially involved in the pathogenesis of xerophthalmia. The relationship and causality among these factors remain unclear, yet understanding the etiology is conducive to more precise treatment of xerophthalmia. This article will discuss the etiology of xerophthalmia that has been determined so far.