川南地区ABO血型与不同病理类型肺癌的关系

Relationship between ABO blood group and different pathological types of lung cancer in Southern Sichuan

摘要:

目的 探讨川南地区ABO血型与不同病理类型肺癌的关系。方法 回顾性分析西南医科大学附属医院2017年8月—2020年12月收治的903例肺癌患者（肺癌组）的临床资料和ABO血型。根据病理类型将肺癌组分为小细胞肺癌组（n =154）和非小细胞肺癌组（n =749），后者再分为肺腺癌组（n =442）、肺鳞癌组（n =307）。选取该院同期1 061例健康体检者为对照组。比较各肺癌组与对照组的ABO血型分布。结果 肺鳞癌组的ABO血型分布为A型（31.9%）、B型（39.7%）、O型（21.2%）、AB型（7.2%），对照组的ABO血型分布为A型（32.2%）、B型（24.4%）、O型（35.7%）、AB型（7.6%），两组的血型构成比较，差异有统计学意义（P <0.001）。调整年龄、性别、吸烟史及饮酒史后，多因素Logistic回归分析显示：B型血患肺鳞癌的风险较O型血高（P <0.05），年龄< 60岁患肺鳞癌风险较年龄≥ 60岁低（P <0.05），不吸烟者患肺鳞癌风险较吸烟者低（P <0.05）。小细胞肺癌组、肺腺癌组与对照组ABO血型构成比较，差异无统计学意义（P >0.05）。结论 川南地区ABO血型与肺鳞癌的发生可能有相关性，与小细胞肺癌、肺腺癌无相关性。

Abstract:

Objective To explore the relationship between ABO blood group and different pathological types of lung cancer in south Sichuan.Methods The clinical data and ABO blood types of 903 patients with lung cancer，who were admitted to the Affiliated Hospital of Southwest Medical University between August 2017 and December 2020 were collected retrospectively. According to pathological types, the lung cancer was divided into small cell lung cancer group (n = 154) and non-small cell lung cancer group (n = 749). The latter group was further divided into lung adenocarcinoma group (n = 442) and lung squamous cell carcinoma group (n = 307). The control group was 1,061 healthy population during the same period. The distribution of ABO blood group in lung cancer subgroups were compared with those in the control group.Results The distribution of ABO blood group in the lung squamous carcinoma group was A (31.9%), B (39.7%), O (21.2%), AB（7.2%）. In the control group, the ABO blood group distribution was A (32.2%), B (24.4%), O (35.7%), AB (7.6%). There was significant difference in the ABO blood group distribution (P < 0.001). After adjusting for age, sex, smoking history, and drinking history, multivariate logistic regression indicated that type B had a higher risk of lung squamous carcinoma than type O (P < 0.05). The result showed that the risk of lung squamous carcinoma was lower when the age was < 60, compared with the age ≥ 60. The result showed that non-smokers have a lower risk of lung squamous cell carcinoma than smokers. There were no significant difference in ABO blood group distribution between small cell lung cancer group, lung adenocarcinoma group, and control group.Conclusion In this study, We found that there was a correlation between ABO blood group and the occurrence of lung squamous cell carcinoma in Southern Sichuan, but no relationship with small cell lung cancer and lung adenocarcinoma.