转录因子Yin Yang-1在头颈部肿瘤的研究进展

Research progress of transcription factor Yin yang-1 (YY1) in head and neck cancer

摘要:

Yin Yang-1（YY1）是一种锌指蛋白，是GLI-Krüppel家族的成员，其可以作为转录抑制因子、激活因子或启动因子结合蛋白，指导并启动细胞和病毒基因的转录。因YY1的表达及功能与细胞周期的进展密切相关，最近被广泛应用于肿瘤生物学模型中。一些证据表明，YY1的表达和/或激活除了在正常的生物学过程中起调节作用外，还与肿瘤的发生有关。该文主要对YY1在转录调控、胚胎发育作用及其在头颈部肿瘤中的研究进展做一综述。

Abstract:

Yin Yang-1 (YY1) is a zinc finger protein and a member of the GLI-Krüppel family which can act as a transcriptional repressor, an activator or promoter binding protein to direct and initiate transcription of many cell and viral genes. It has recently been widely used in tumor biological models, because its expression and function are closely related to the cell cycle progress. Some evidence shows that, in addition to playing a regulatory role in normal biological processes, the expression and/or activation of YY1 is also associated with tumorigenesis. This paper mainly reviews the research progress of YY1 in transcriptional regulation, embryonic development and its application in head and neck cancer.