脑出血患者外周血microRNA-7表达的变化及其与近期预后的关系

Changes of microRNA-7 expression in peripheral blood of patients with cerebral hemorrhage and its correlation with short-term prognosis

摘要:

目的 研究脑出血患者外周血microRNA-7（miR-7）表达的变化及其与近期预后的关系。方法 选择2015年3月—2019年3月新疆医科大学第一附属医院收治的65例自发性脑出血患者作为脑出血组，同期体检的55例健康志愿者作为对照组。检测两组研究对象外周血miR-7的表达；随访脑出血患者的短期预后并根据出院后90 d的改良Rankin量表（mRS）评分分为mRS< 3分的预后良好患者和≥ 3分的预后不良患者，分析预后不良的影响因素及miR-7对预后不良的预测价值。结果 脑出血组外周血miR-7的表达水平低于对照组（P <0.05）；脑出血组中预后不良患者的入院时GCS评分、外周血miR-7的表达水平、早期肠内营养比例低于预后良好患者（P <0.05），随机血糖、hs-CRP、初始血肿体积、出血破入脑室比例高于预后良好患者（P <0.05）；miR-7表达减少及随机血糖、hs-CRP增加是预后不良的危险因素，早期肠内营养是预后不良的保护因素（P <0.05）；miR-7表达减少对短期预后不良具有预测价值（P <0.05）。结论 脑出血患者外周血miR-7表达减少且是短期预后不良的危险因素、对短期预后不良具有预测价值。

Abstract:

Objective To study the expression of miR-7 in the peripheral blood of patients with cerebral hemorrhage and its correlation with the recent prognosis.Methods Totally 65 patients with spontaneous intracerebral hemorrhage from March 2015 to March 2019 were selected as the intracerebral hemorrhage group, and 55 healthy volunteers as the control group. The expression of miR-7 in peripheral blood was detected. The short-term prognosis of patients with intracerebral hemorrhage was followed up, and the patients were classified as good prognosis with mRS < 3 and no prognosis with mRS ≥ 3 according to the modified Rankin Scale (mRS) score of 90 days after discharge. The influencing factors of poor prognosis and the predictive value of miR-7 for poor prognosis were analyzed.Results The expression level of miR-7 in the peripheral blood of the cerebral hemorrhage group was significantly lower than that of the control group (P < 0.05); the GCS score, the expression level of miR-7 in the peripheral blood and the proportion of early enteral nutrition of the patients with poor prognosis in the cerebral hemorrhage group were significantly lower than those of the patients with good prognosis (P < 0.05); the random blood glucose, hs-CRP, initial hematoma volume, and the proportion of bleeding into the ventricle were significantly higher than those of the patients with good prognosis (P < 0.05); decreased miR-7 expression, increased random blood glucose, and hs-CRP were the risk factors for poor prognosis, early enteral nutrition was the protective factor for poor prognosis (P < 0.05), and the decreased expression of miR-7 had predictive value for short-term poor prognosis.Conclusion The decreased expression of miR-7 in the peripheral blood of patients with cerebral hemorrhage is a risk factor for poor short-term prognosis and has a predictive value for poor short-term prognosis.