生物钟基因Rev-erb和ROR在抗炎及免疫调节中的作用研究进展

Role of circadian clock genes Rev-erb and ROR in anti-inflammatory and immune regulation

摘要:

生物钟广泛存在于生物体，调节生物的生长发育。随着生物钟分子机制的逐步明确，学者发现生物钟基因Rev-erb和ROR参与许多生理过程，并在抗炎及免疫调节过程中发挥重要作用。针对该类受体的靶向研究可用于调控机体免疫。该文重点介绍生物钟基因Rev-erb和ROR在抗炎及免疫调节中的作用，包括该受体的相关作用机制及针对该受体的配体研究。

Abstract:

Circadian clocks exist widely in organisms and regulate the growth and development of organisms. With the gradual clarification of the molecular mechanism of the circadian clock, scholars have discovered that the circadian clock genes Rev-erb and ROR participate in many physiological processes and play an important role in the process of anti-inflammatory and immune regulation. Targeting research on these receptors can be used to regulate the body's immunity. This article focuses on the research of circadian clock genes Rev-erb and ROR in anti-inflammatory and immune regulation, including the mechanism of action of this receptor and the ligand research for this receptor.