RNA结合蛋白ELAVL1与肿瘤进展的关系研究

Review on relationship between RNA-binding protein ELAVL1 and tumor progression

摘要:

胚胎致死性异常视觉样蛋白1（ELAVL1/HuR）是一种RNA结合蛋白，通过与特定的mRNA结合参与转录后调控，从而影响细胞增殖、凋亡、分化等生物学行为。近年来研究表明，ELAVL1与肿瘤细胞的增殖、血管生成、侵袭、转移及耐药性明显相关。本文就ELAVL1蛋白与肿瘤进展关系展开综述。

Abstract:

ELAVL1/HuR is a kind of RNA-binding protein, which belongs to a member of the embryonic lethal abnormal vision (ELAV) family. It selectively stabilizes particular mRNAs and involves in post-transcriptional regulation to mediate a variety of cell behaviors including proliferation, apoptosis, and differentiation. Recent studies show that ELAVL1 is closely related to tumor proliferation, neoangiogenesis, invasion, metastasis, and resistance to cancer therapy. This review gives an overview on the relationship between ELAVL1 and tumor progression.