NR4A家族蛋白结构与功能的研究进展

Research progress of structure and function of NR4A subfamily

摘要:

孤儿核受体NR4A家族蛋白是一类不依赖于配体激活的主动转录因子，其本身的表达、转录、翻译后修饰（磷酸化、泛素化等过程）可被多种外界刺激激活。激活后的NR4A以单体或二聚体形式识别并结合下游靶基因的启动子调控其转录与表达，调节机体代谢、免疫反应，参与肿瘤等多种疾病的发生、发展，可能成为肿瘤治疗的潜在药物。该文从结构和功能两方面对NR4A家族蛋白的研究进展进行综述。

Abstract:

Orphan nuclear receptor NR4A subfamily is a kind of ligand independent transcription factors. The expression, transcription, and post-translational modification (phosphorylation, ubiquitination, etc.) of NR4A can be activated by a variety of external stimuli. NR4A proteins recognize the promoter region of the downstream target gene as monomer or dimers to regulate its transcription and expression. NR4A proteins regulate the metabolism and immune response, and participate in the occurrence and development of various diseases. NR4A proteins may be a new target for cancer treatment. In this paper, we reviewed the research progress in the structure and function of NR4A family proteins.