钙基抗菌多肽复合物凝胶治疗头皮脂溢性皮炎的疗效观察

Clinical effect of calcium-based antimicrobial polypeptide compounds gel on scalp seborrheic dermatitis

摘要:

目的 探讨钙基抗菌多肽复合物凝胶对糠秕马拉色菌的抑制作用及其治疗头皮脂溢性皮炎的临床疗效和安全性。方法 采用体外抑菌实验检测钙基抗菌多肽复合物凝胶抑制糠秕马拉色菌的有效性和最低抑菌浓度。选取2019年3月—2019年10月中日友好医院皮肤病与性病科门诊60例头皮脂溢性皮炎患者，根据治疗方案分为实验组和对照组，每组30例。实验组外用钙基抗菌多肽复合物凝胶，对照组外用钙基抗菌多肽复合物凝胶基质，两组产品直接涂抹于患者皮损部位，3次/d，治疗4周。记录两组患者治疗前后的症状评分，评价整体临床疗效，并记录不良事件。结果 体外抑菌实验结果表明，钙基抗菌多肽复合物凝胶对糠秕马拉色菌具有抑制性，最低抑菌浓度为0.3 mg/ml。临床研究结果表明，治疗前，两组症状评分及真菌镜检结果无统计学意义。连续治疗4周后，实验组有效率为85.19%，对照组有效率为52.17%，两组比较差异有统计学意义（P <0.05）。两组患者治疗前后各症状评分差值比较，差异有统计学意义（P <0.05），实验组真菌镜检阴转率高于对照组（P <0.05）。两组均未发生任何不良反应。结论 钙基抗菌多肽复合物凝胶对糠秕马拉色菌具有抑制作用，能减轻脂溢性皮炎患者的痛苦，是一种治疗头皮脂溢性皮炎安全、有效的辅助方法。

Abstract:

Objective To explore the inhibitory effect of calcium-based antimicrobial polypeptide compounds gel on Malassezia and its clinical efficacy and safety in treating seborrheic dermatitis.Methods In vitro bacteriostatic experiment: to explore the effectiveness and minimum bacteriostatic concentration of calcium-based antimicrobial polypeptide compounds gel on inhibiting Malassezia. Clinical studies: 60 selected patients with head dermatitis seborrheica were randomly divided into experimental group and control group, 30 cases in each group. The experimental group was externally applied with calcium-based antimicrobial polypeptide compounds gel, and the control group was externally applied with gel matrix. And both of them were directly applied on the skin lesions, 3 times a day for 4 weeks. The changes of symptoms before and after treatment, the occurrence of adverse reactions, and the overall clinical efficacy of the two groups were recorded and evaluated.Results In vitro bacteriostatic experiments show that calcium-based antimicrobial polypeptide compounds gel was effective against Malassezia, the minimum inhibitory concentration was 0.3 mg/ml. Clinical research results: Before treatment, the symptom scores and mycoscopic examination results of the two groups were not statistically significant. After 4 weeks of continuous treatment, the effective rate of the experimental group was 85.19%, and the effective rate of the control group was 52.17%. There was a significant difference between the two groups (P < 0.05). After 4 weeks of treatment, there were significant differences in the differential value of symptom scores between the two groups before and after treatment (P < 0.05), and the negative conversion rate of mycoscopy was also significantly higher than the control group (P < 0.05). No adverse reactions occurred in the two groups.Conclusion The calcium-based antimicrobial polypeptide compounds gel has an inhibitory effect on Malassezia furfur, can alleviate the pain of patients with seborrheic dermatitis, and is a safe and effective auxiliary method for the treatment of scalp seborrheic dermatitis.