结直肠癌免疫逃逸机制的研究进展

Advances in research on immune escape mechanism of colorectal cancer

摘要:

结直肠癌是世界第3大常见的癌症。最近10年我国结直肠癌发病率和病死率均有所增加，迫切需要降低患者发病率或延长患者的生存期。随着免疫治疗的成功，越来越多的研究证实结直肠癌的进展与肿瘤微环境有密切的关系。肿瘤抑制抗肿瘤免疫反应并产生逃离的机制极为复杂。该文主要对结直肠癌免疫应答机制和肿瘤细胞免疫逃逸机制的研究进展进行综述。

Abstract:

Colorectal cancer is the third most common cancer in the world. Both morbidity and mortality have increased in the past decade in China. Therefore, it is an urgent need for clinical treatment to reduce the incidence of patients or prolong the survival of patients. With the success of immunotherapy, more studies have confirmed that the progress of colorectal cancer is closely related to the tumor microenvironment. The mechanism by which tumors suppress anti-tumor immune responses and generate escapes is extremely complex. This review is mainly to discuss and analyze the research progress of the immune response mechanism of colorectal cancer and the immune escape.