2种化疗方案治疗晚期上皮性卵巢癌的临床研究

Comparison of efficacy of different chemotherapy regimens in the treatment of advanced epithelial ovarian cancer

摘要:

目的 探讨不同化学药物治疗（以下简称化疗）方案治疗晚期上皮性卵巢癌的疗效。方法 选取2017年7月－2019年6月在海南省第三人民医院就诊的晚期上皮性卵巢癌患者93例，所有患者都是初治且行肿瘤细胞减灭术。术后常规化疗，一组为紫杉醇+卡铂（TC组），另一组为紫杉醇+顺铂（TP组）。比较不同化疗方案对患者的临床疗效及其主要毒副反应。结果 TC组有效率为68.9%（31/45），TP组为70.8%（34/48），差异无统计学意义（P >0.05）。TC组骨髓抑制率（48.9%）高于TP组（35.4%）（P <0.05）；两组>60岁患者的骨髓抑制率比较，差异无统计学意义（P >0.05）。TP组消化道反应发生率（37.5%）高于TC组（24.4%）（P <0.05）。结论 TC和TP方案对晚期上皮性卵巢癌均疗效确切，TP组骨髓抑制发生率低于TC组，TP组虽然总体消化道反应发生率高于TC组，但主要是Ⅰ级和Ⅱ级消化道反应，患者尚可耐受。

Abstract:

Objective To investigate the therapeutic effect of different chemotherapy regimens in the treatment of advanced epithelial ovarian cancer.Methods Ninety-three patients with advanced epithelial ovarian cancer in Hainan Third People's Hospital from July 2017 to June 2019 were selected and all of them were treated with cytoreductive surgery followed by conventional chemotherapy. According to the different chemotherapy regimens, the patients were divided into TC group (paclitaxel and carboplatin) and TP group (paclitaxel and cisplatin). Clinical efficacy and adverse reactions were assessed after treatment.Results The effective rate was 68.9% (31/45) and 70.8% (34/48) in TC group and TP group, respectively, with no significant difference between the groups (P > 0.05). The rate of bone marrow suppression in TC group (48.9%) was higher than that in TP group (35.4%) (P < 0.05). However, there was no significant difference in the rate of bone marrow suppression in patients older than 60 years between the two groups (P > 0.05). Besides, the incidence of gastrointestinal reactions in TP group (37.5%) was higher than that in TC group (24.4%) (P < 0.05).Conclusions TC and TP regimens have definite curative effects on advanced epithelial ovarian cancer. TP regimen leads to lower rate of bone marrow suppression in comparison to TC regiment. Although TP regimen induces a higher incidence of gastrointestinal reactions, they are mainly grade Ⅰ and Ⅱ reactions which are relatively well-tolerated.