组学技术在银屑病研究中的应用

Application of multi-omics in psoriasis research

摘要:

银屑病作为一种难治性免疫相关炎症性皮肤病，具有病程缠绵反复、易诱发其他严重并发症、遗传倾向等特征，但其发病机制及发生发展中的治疗靶标尚无定论。目前各种高通量技术蓬勃发展，多组学技术应运而生，可为疾病研究提供更全面的证据。银屑病相关的多组学研究包括代谢组学、蛋白质组学、基因组学、表观遗传学、肠道微生物组学、转录组学等，该文对这些组学技术在银屑病研究中的应用作一综述。

Abstract:

Psoriasis is a kind of refractory immune-related inflammatory skin disease, it has the characteristics of repetitive course, easy to induce other serious complications, and has genetic predisposition. However, the pathogenesis and therapeutic targets in the disease development process are still inconclusive. At present, various high-throughput technologies are booming, and multi-omics technologies have emerged at the historic moment, which can provide more comprehensive evidences for disease research. This article reviews the advances in multi-omics studies related to psoriasis research, including metabonomics, proteomics, genomics, epigenetics, intestinal-microbiomics, and transcriptomics.