环状RNA在心力衰竭心肌重构中的作用

Research progress of the effects of circular RNA on myocardial remodeling in heart failure

摘要:

环状RNA是一类呈共价闭合结构的非编码RNA，其具有分布广泛、多样化、不易被核酸酶降解、稳定和高度保守等生物学特点。心力衰竭发生、发展的基本机制是心肌重构。研究表明，环状RNA可通过影响心肌纤维化、心肌细胞肥大、心肌损伤和凋亡等病理机制来参与心力衰竭的发生、发展，有望成为心力衰竭新的生物标记物及治疗靶点。该文将从环状RNA的生物学特性、形成机制、生物学功能及在心力衰竭心肌重构中的研究作一综述。

Abstract:

Circular RNA (circRNA) is a kind of non-coding RNA with covalently closed structure, and is characterized as widely distributed, diversified, not easily degraded by nuclease, stable and highly conservative. The researches have shown that circRNA participates in the pathophysiological process of heart failure by influencing myocardial fibrosis, hypertrophy of cardiac cells, myocardial injury and apoptosis. Therefore, it is promising to become a new biomarker and treatment target of heart failure. This paper will review the biological characteristics, formation mechanism and biological function of circRNA and advances on the roles of circRNA in heart failure.