2型糖尿病肾病患者血清NF-κB、MDA水平及其与肾功能的关系探讨

Detection of serum NF-κB and MDA levels in patients with type 2 diabetic nephropathy and their relationships with renal function

摘要:

目的 探讨2型糖尿病肾病（T2DN）患者血清核因子-κB（NF-κB）、丙二醛（MDA）水平及其与肾功能的关系。方法 选取2018年3月—2019年10月徐州市中心医院收治的初诊T2DN患者96例作为DN组，同期该院单纯2型糖尿病患者52例为DM组，另选取同期该院体检健康者52例作为NC组。比较3组血清NF-κB和MDA水平；比较3组肾功能相关指标；Pearson法分析T2DN患者血清NF-κB、MDA水平与肾功能的相关性。结果 3组血清NF-κB和MDA水平比较，差异有统计学意义（P <0.05），DN组高于DM组和NC组（P <0.05），DM组与NC组比较，差异无统计学意义（P >0.05）；3组Scr、β₂-MG、BUN、eGFR及UAER水平比较，差异有统计学意义（P <0.05），DN组Scr、β₂-MG、BUN、UAER水平高于DM组和NC组（P <0.05），DN组eGFR水平低于DM组和NC组（P <0.05），DM组与NC组比较，差异无统计学意义（P >0.05）；Pearson相关分析结果显示：T2DN患者血清NF-κB与Scr、β₂-MG、BUN、UAER呈正相关（r =0.816、0.943、0.836和0.735，均P <0.05）；与eGFR呈负相关（r =-0.736，P <0.05）。MDA与Scr、β₂-MG、BUN、UAER呈正相关（r =0.723、0.816、0.917和0.726，均P <0.05）；与eGFR呈负相关（r =-0.829，P <0.05）。结论 T2DN患者血清NF-κB、MDA水平及Scr、β₂-MG、BUN、eGFR、UAER水平均有异常，且血清NF-κB、MDA与Scr、β₂-MG、BUN、eGFR、UAER均存在相关性。

Abstract:

Objective To explore the relationships of serum NF-κB and MDA levels with renal function in patients with type 2 diabetic nephropathy (T2DN).Methods From March 2018 to October 2019, 96 newly diagnosed patients with T2DN in our hospital were selected as DN group, and 52 patients with simple type 2 diabetes nephropathy (T2DM) and 52 healthy persons were selected as DM group and NC group. Renal function, serum NF-κB and MDA levels were compared in three groups. Pearson correlation analysis was used to explore the correlation of serum NF-κB and MDA levels with renal function indexes in T2DN patients.Results The levels of serum NF-κ B and MDA were significantly different among the three groups (P < 0.05); those were higher in DN group than in DM group and NC group (P < 0.05); there was no statistical difference between DM group and NC group (P > 0.05). The levels of Scr, β₂-MG, BUN, eGFR, and UAER were significantly different among the three groups (P < 0.05); the levels of Scr, β₂-MG, BUN, and UAER in DN group were higher than those in DM group and NC group (P < 0.05), and eGFR level in DN group was significantly lower than that in DM group and NC group (P < 0.05). There was no significant difference in SCR, β₂-MG, BUN, eGFR, and UAER levels between DM group and NC group (P > 0.05). Person correlation analysis showed that serum NF-κ B was positively correlated with Scr (r = 0.816), β₂-MG (r = 0.943), BUN (r = 0.836), UAER (r = 0.735) (P < 0.05), and negatively correlated with eGFR (r = -0.736, P < 0.05). MDA was positively correlated with Scr (r = 0.723), β₂-MG (r = 0.816), BUN (r = 0.917), and UAER (r = 0.726) (P < 0.05), and negatively correlated with eGFR (r = -0.829, P < 0.05).Conclusion The levels of NF-κ B and MDA, Scr, β₂-MG, BUN, eGFR, and UAER are abnormal in T2DN patients, and the levels of NF-κ B and MDA are correlated with the above renal function indexes.