MicroRNA与生精障碍的研究进展

Research progress of microRNA and male spermatogenesis disorderWen-wen Sun1, Zhou-cun A2

摘要:

MicroRNA（miRNA）是一类长度为20～25个核苷酸的内源性非编码RNA，主要在转录后和翻译水平上调控基因表达。许多研究表明，miRNA在生精过程中发挥重要的调控作用，miRNA的异常影响精子形成的多个阶段和不同的细胞类型，导致生精障碍，引起男性不育。现将近年来miRNA在精子发生和生精障碍领域的研究文献作一综述。并介绍miRNA在精子发生中的作用及其与生精障碍的关系，以及miRNA在生精障碍性疾病领域的诊断和治疗潜力。

Abstract:

MicroRNA (miRNA) is a type of non-endogenous coding RNA with 20 to 25 nucleotides, which mainly regulates gene expression at post-transcriptional and translation levels. Many studies have shown that miRNA plays an important regulatory role in the process of spermatogenesis. miRNA abnormalities affect multiple stages of sperm formation and different cell types, leading to spermatogenesis disorders, which in turn cause male infertility. This article reviews the recent literature on miRNA in the field of speratogenesis. To introduce the role of miRNA in spermatogenesis and its relationship with spermatogenesis disorders, as well as the diagnostic and therapeutic potential of microRNA in the field of spermatogenesis disorders.