轻度哮喘持续患儿血清镁水平与症状控制及肺功能关系的研究

Relationship between serum magnesium level and lung function in children with mild asthma

摘要:

目的 探讨轻度哮喘持续患儿血清镁水平与症状控制及肺功能的关系。方法 选取2017年1月—2019年12月绵阳市中心医院收治的320例轻度哮喘持续患儿为研究对象。所有患儿均行肺功能检测，入院后完成血清镁水平检测。采用儿童哮喘控制测试问卷（ACT）进行症状控制评估。根据ACT评分将患儿分为控制良好组、部分控制组及未控制组。分析比较症状控制不同患儿肺功能、血清镁水平的差异。结果 全组患儿血清镁水平为1.5～2.5 mg/dL，低镁血症的患病率为5.31%（17/320）。不同哮喘控制组的第1秒钟用力呼气容积占用力肺活量比值（FEV₁/FVC）、FEV₁%预测值、呼气流速峰值（PEFR）及ACT评分比较，差异有统计学意义（P <0.05），控制良好组高于部分控制组和未控制组（P <0.05）。多因素Logistic回归分析结果显示，留守儿童［O^R=2.065（95% CI：1.119，3.974）］、家族史［O^R=2.317（95% CI：1.214，4.482）］、病程［O^R=2.353（95% CI：1.329，5.215）］、治疗时间［O^R=2.147（95% CI：1.032，4.978）］、合并过敏性鼻炎［O^R=2.587（95% CI：0.214，3.365）］、治疗依从性［O^R=1.934（95% CI：1.021，3.368）］是影响哮喘患儿病情控制的独立危险因素（P <0.05）。Spearman相关性分析结果显示，ACT评分与FEV₁、PEFR呈正相关（r_s =0.399和0.246，均P <0.05）。血清镁水平与ACT评分、FEV₁、PEFR无相关（P >0.05），与治疗时间呈负相关（r_s =-0.162，P <0.05）。结论 轻度哮喘持续患儿存在一定的低镁血症发生率，但血清镁水平与哮喘症状控制之间没有相关性。

关键词:支气管哮喘;肺功能;血清镁

Abstract:

Objective To investigate the relationship between serum magnesium level and pulmonary function in children with mild asthma.Methods A total of 320 children with mild asthma were selected as the study object. All the children were tested for lung function and serum magnesium level after admission. Symptom control was performed with the child asthma control test questionnaire (ACT). According to the ACT score, the children were divided into well controlled group, partial control group, and uncontrolled group. The differences of pulmonary function and serum magnesium level in children with different symptom control levels were analyzed and compared.Results The total serum magnesium level range was 1.5 to 2.5 mg/dL, and the prevalence of hypomagnesemia was 5.31% (17/320). The ratio of forced expiratory volume in forced vital capacity (FEV₁ / FVC), predicted value of FEV₁%, peak expiratory flow rate (PEFR), and act score in the first second in different asthma control groups were significantly different (P < 0.05), and those in the well controlled group were higher than those in partial control groups and uncontrolled groups (P < 0.05). Multivariate logistic regression analysis showed whether it was left behind children [O^R = 2.065 (95% CI: 1.119, 3.974) ], whether it had family history [O^R = 2.317 (95% CI: 1.214, 4.482) ], duration of disease [O^R = 2.353 (95% CI: 1.329, 5.215) ], treatment time [O^R = 2.147 (95% CI: 1.032, 4.978) ], whether it was complicated with allergic rhinitis [O^R = 2.587 (95% CI: 0.214, 3.365) ], and treatment compliance [O^R = 1.934 (95% CI: 1.021, 3.368) ] were independent risk factors affecting the control level of children with asthma (P < 0.05). Spearman correlation analysis showed that ACT score was positively correlated with FEV₁ and PEFR (r_s = 0.399 and 0.246, all P < 0.05). Serum magnesium level was not correlated with ACT score, FEV₁, and PEFR (P > 0.05), but negatively correlated with treatment time (r_s = -0.162, P < 0.05).Conclusion There is a certain incidence of hypomagnesemia in mild persistent children, but there is no significant correlation between serum magnesium level and asthma symptom control.

Key words:asthma, bronchial;pulmonary function;serum magnesium