Abstract:Objective To investigate the efficacy and safety of subgaleal drainage as a therapeutic strategy of chronic subdural hematoma.Methods The incidence of postoperative complications, hematoma recurrence, prognosis, and subdural hematoma were analyzed in 98 patients with subdural drainage and 82 patients with subgaleal drainage during the follow-up period from January 2015 to December 2019 in our hospital.Results There were differences in the postoperative cerebral cortex injury rate between the two groups (P < 0.05), both groups showed decrease of hematoma thickness (P < 0.05), indicated the same efficacy of hematoma resolution in two groups (P > 0.05), however subgaleal drainage took less time in operation (P < 0.05). And there were no statistically significant differences in the second operation, postoperative infection, epileptic seizure, mortality, hematoma recurrence and MRS score at 6 months after surgery (P > 0.05).Conclusions Subgaleal drainage has the same effect as subdural drainage in the treatment of chronic subdural hematoma, but subgaleal drainage performs more simply and safety, and shows the potential in clinical therapy of chronic subdural hematoma.