厚朴排气合剂对老年2型糖尿病胃轻瘫患者胃肠激素、胃动力和氧化应激的影响

Effects of Houpo Paiqi Mixture on gastrointestinal hormones, gastrointestinal dynamics and oxidative stress in elderly patients with type 2 diabetic gastroparesis

摘要:

目的 探讨厚朴排气合剂对老年2型糖尿病胃轻瘫患者胃肠激素、胃动力和氧化应激的影响。方法 选取2019年6月—2020年6月浙江省人民医院收治的老年2型糖尿病胃轻瘫患者80例，按照随机抽签法分为实验组和对照组，每组40例。两组患者维持注射胰岛素或口服降糖药等常规降糖治疗，且进行适量运动，合理饮食。对照组患者口服枸橼酸莫沙必利片，实验组在对照组基础上口服厚朴排气合剂，均治疗4周。比较两组治疗4周后主要症状积分、胃肠激素、胃动力和氧化应激水平的变化。结果 实验组治疗总有效率（92.50%）高于对照组（70.00%）（P <0.05）。实验组治疗前后空腹血糖、餐后2 h血糖和糖化血红蛋白的差值大于对照组（P <0.05）。实验组治疗前后胃脘胀满、纳呆和嗳气积分的差值大于对照组（P <0.05）。实验组治疗前后生长抑素、胃动素和促胃液素的差值大于对照组（P <0.05）。实验组治疗前后胃排空时间、胃排空率和胃收缩频率的差值大于对照组（P <0.05）。实验组治疗前后超氧化物歧化酶和谷胱甘肽过氧化物酶的差值大于对照组（P <0.05）。结论 厚朴排气合剂治疗老年2型糖尿病胃轻瘫患者疗效良好，可改善患者胃肠激素和胃动力，调节氧化应激水平。

Abstract:

Objective To investigate the effects of Houpo Paiqi Mixture on gastrointestinal hormones, gastrointestinal dynamics and oxidative stress in elderly patients with type 2 diabetic gastroparesis.Methods The 80 elderly patients with type 2 diabetic gastroparesis in Zhejiang Provincial People's Hospital from June 2019 to June 2020 were randomly divided into experimental group (40 cases) and control group (40 cases). The two groups of patients continued to receive insulin injection or oral hypoglycemic drugs and other conventional hypoglycemic therapy, with appropriate exercise and reasonable diets. The control group was treated with Mosapride tablets, while the experimental group was treated with Houpo Paiqi Mixture on the basis of the treatments in the control group. The treatment course of the two groups was 4 weeks. The overall effective rate was compared between the two groups after 4 weeks of treatment; the changes in main symptom scores, gastrointestinal hormones, gastrointestinal dynamics and oxidative stress levels before and after 4 weeks of treatment were compared.Results The overall effective rate of experimental group (92.50%) was higher than that of control group (70.00%) (P < 0.05). The differences of fasting blood glucose (FBG), two-hour postprandial glucose (2 hPG) and glycated hemoglobin (HbA1c) before and after treatment in the experimental group were higher than those in the control group (P < 0.05). The differences of epigastric fullness, anorexia and belching scores before and after treatment in the experimental group were higher than those in the control group (P < 0.05). The differences of somatostatin, motilin and gastrin levels before and after treatment in the experimental group were higher than those in the control group (P < 0.05). The differences of gastric emptying time, gastric emptying rate and gastric contraction frequency before and after treatment in the experimental group were higher than those in the control group (P < 0.05). Besides, the differences of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) levels before and after treatment in the experimental group were higher than those in the control group (P < 0.05).Conclusions Houpo Paiqi Mixture shows great therapeutic efficacy in elderly patients with type 2 diabetic gastroparesis, improves gastrointestinal hormones and gastrointestinal dynamics, and regulates the level of oxidative stress.