IL-6基因多态性与帕金森病预后的关系

Relationship between IL-6 gene polymorphism and prognosis of Parkinson's disease

摘要:

目的 探讨IL-6基因rs1800796多态性与帕金森病预后的关系。方法 收集2017年1月—2019年12月聊城市人民医院就诊的帕金森病患者80例作为帕金森病组；同期收集该院体检的健康志愿者50例作为对照组。检测患者IL-6基因C-572G位点（rs1800796）的多态性，比较两组研究对象基因型频率和等位基因频率的差异，分析IL-6不同基因型帕金森患者经美多巴治疗后的疗效差异。结果 帕金森病组IL-6基因C-572G位点（rs1800796）CC野生型和等位基因C频率低于对照组（均P <0.05），而GG纯合型和等位基因G频率高于对照组（均P <0.05）。美多芭治疗前、后UPDRS、PDQ-39、MMSE和MoCA评分CC型最低，CG型次之，而GG型最高（P <0.05）。结论 IL-6基因C-572G位点（rs1800796）多态性与帕金森病预后均存在密切的关系，发生鸟嘌呤核苷酸（G）突变患者具有更为严重的病情。

Abstract:

Objective To investigate the relationship between IL-6 gene (rs1800796) polymorphism and the clinical features of Parkinson's disease and the prognosis of Madopar treatment.Methods From January 2017 to December 2019, 80 patients with Parkinson's disease (PD group) were collected in our hospital, and 50 healthy volunteers who came to our hospital for physical examination at the same time were selected as the control group. The differences of genotype frequency and allele frequency between the two groups were compared, and the therapeutic effect of different IL-6 genotypes after Madopar treatment was analyzed.Results The percentages of CC wild type and allele C frequency at C-572G site of IL-6 gene (rs1800796) in patients with Parkinson's disease were lower than those in control group, while the frequencies of GG homozygote and allele G were higher than those in control group (P < 0.05). The serum IL-6, UPDRS, PDQ-39, MMSE, and MOCA scores were the lowest in CC group, followed by CG group and the highest in GG group (P < 0.05).Conclusion The effect of Madopar on Parkinson's disease is remarkable. The C-572G polymorphism of IL-6 gene (rs1800796) is closely related to the clinical characteristics of Parkinson's disease and the prognosis of Madopar treatment. Patients with guanine nucleotide (G) mutation have more serious disease condition.