妊娠糖尿病患者血清Betatrophin、Omentin-1水平与糖脂代谢及胰岛素抵抗的相关性

Relationship of serum betatrophin and omentin-1 with glycolipid metabolism and insulin resistance for gestational diabetes mellitus

摘要:

目的 探讨妊娠糖尿病（GDM）患者血清Betatrophin、脂肪组织中网膜素１（Omentin-1）水平变化特点，分析其与糖脂代谢和胰岛素抵抗的相关性。方法 选择2019年5月—2020年8月承德市中心医院妇产科接诊的179例孕妇。采用酶联免疫吸附试验检测所有孕妇妊娠10～14周血清Betatrophin、Omentin-1水平。所有孕妇妊娠24～26周进行口服葡萄糖糖耐量试验（OGTT），其中，119例被诊断为GDM（GDM组），60例血糖水平正常的孕妇为对照组。检测两组孕妇的总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG）、空腹胰岛素（FINS）及糖化血红蛋白（HbA1c）水平。采用稳态模型计算胰岛素抵抗指数（HOMA-IR）。分析Betatrophin、Omentin-1与GDM患者糖脂代谢指标的相关性。多元线性逐步回归分析GDM患者HOMA-IR的影响因素。结果 GDM组孕前体重指数（BMI）、FBG、FINS、HOMA-IR、HbA1c、TC、LDL-C、Betatrophin水平高于对照组（P <0.05），Omentin-1水平低于对照组（P <0.05）。相关性分析结果显示GDM患者血清Betatrophin与TG（r_s =0464）、HOMA-IR（r =0.610）、LDL-C（r =0.512）呈正相关（均P <0.05），Omentin-1水平与孕前BMI（r_s =-0.304）、LDL-C（r =-0.543）、FBG（r =-0.475）、FINS（r =-0.435）、HOMA-IR（r =-0.576）呈负相关（均P <0.05）。多元线性逐步回归分析结果显示TG、LDL-C、Betatrophin、Omentin-1是GDM患者HOMA-IR的影响因素（P <0.05）。结论 GDM患者血清Betatrophin水平升高，Omentin-1水平降低，Betatrophin、Omentin-1均与GDM患者糖脂代谢、胰岛素抵抗有关。

Abstract:

Objective To investigate the changes of in serum level of Betatrophin and Omentin-1 of gestational diabetes mellitus (GDM), and to analyze the correlation of Betatrophin and Omentin-1 with glycolipid metabolism and insulin resistance.Methods A total of 179 pregnant women were selected from the perinatal outpatient department of Chengde Central Hospital from May 2019 to August 2020. Serum levels of Betatrophin and Omentin-1 were detected by enzyme-linked immunosorbent assay at 10 to 14 weeks of gestation. Oral glucose tolerance (OGTT) was administered at 24 to 26 weeks of gestation, and 119 patients were diagnosed with GDM (GDM group) and 60 with normal OGTT (Control group). The correlation of Betatrophin and Omentin-1 with glucose and lipid metabolism was analyzed in GDM patients.Results The levels of BMI, FBG, fins, HOMA-IR, HbAlc, TC, LDL-C, and Betatrophin in GDM group were higher than those in Control group (P < 0.05), and the levels of Omentin-1 were lower than those in the control group (P < 0.05). Pearson or Spearman correlation analysis showed that serum Betatrophin level was positively correlated with TG (r_s = 0464), HOMA-IR (r = 0.610), LDL-C (r = 0.512) (P < 0.05), Omentin-1 was negatively correlated with pre-pregnancy BMI (r_s = -0.304), LDL-C (r = -0.543), FBG (r = -0.475), FINS (r = -0.435), and HOMA-IR (r = -0.576) (P < 0.05). Multiple linear regression analysis showed that TG, LDL-C, Betatrophin, and Omentin-1 were independently correlated with HOMA-IR in GDM patients (P < 0.05).Conclusion The serum level of Betatrophin of GDM patients of pregnancy is increased, while the level of Omentin-1 is decreased. Betatrophin and Omentin-1 were related to glucose and lipid metabolism and insulin resistance in GDM patients.